Medication·Interactions·Reviewed June 9, 2026
Pseudoephedrine interactions.
Pseudoephedrine has 3 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Pseudoephedrine at a glance.
A quick, data-grounded summary. The full tables are below.
Pseudoephedrine has 3 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with pseudoephedrine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Cocaine | Contraindicated | Pseudoephedrine and cocaine are both sympathomimetic stimulants, so combined use can sharply increase blood pressure, heart rate, vasoconstriction,... details → |
| MDMA | Contraindicated | Pseudoephedrine can add to MDMA's stimulant cardiovascular effects. Controlled human studies show MDMA increases blood pressure, heart rate, and... details → |
| Nicotine | Caution | Pseudoephedrine and nicotine can both raise heart rate, blood pressure, and sympathetic tone. Pseudoephedrine has a measurable pressor and... details → |
The full pseudoephedrine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common pseudoephedrine questions.
Quick answers drawn from the tables above.
What interacts with Pseudoephedrine?
In the NutriStack database, Pseudoephedrine has 3 documented interactions. The most notable include Cocaine, MDMA, and Nicotine. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Pseudoephedrine?
Pseudoephedrine is flagged against 2 substances in the database, including Cocaine and MDMA. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Cocaine with Pseudoephedrine?
NutriStack classifies the Cocaine and Pseudoephedrine pairing as contraindicated: Pseudoephedrine and cocaine are both sympathomimetic stimulants, so combined use can sharply increase blood pressure, heart rate, vasoconstriction, and myocardial... Do not use pseudoephedrine if you have used cocaine or may use cocaine soon. Seek urgent care for chest pain, severe headache, fainting, severe... Always confirm with your prescriber.
Check your whole stack
See how pseudoephedrine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.