Medication·Interactions·Reviewed June 9, 2026
Quetiapine interactions.
Quetiapine has 5 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Quetiapine at a glance.
A quick, data-grounded summary. The full tables are below.
Quetiapine has 5 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with quetiapine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Contraindicated | St. John's Wort is a potent CYP3A4 inducer that can reduce quetiapine plasma concentrations by up to 80%, essentially rendering the medication... details → |
| Cannabis (THC-Dominant) | Conflict | THC-dominant cannabis can conflict with quetiapine's use for psychosis or bipolar mood stabilization. Continued cannabis use after psychosis onset... details → |
| Alcohol | Caution | Alcohol can markedly increase quetiapine-related sleepiness, dizziness, slowed reactions, and poor coordination. Quetiapine's antihistamine and... details → |
| Melatonin | Caution | Both quetiapine and melatonin have sedative properties, and their combination produces additive CNS depression. Quetiapine is particularly sedating... details → |
| Valerian Root | Caution | Valerian root has GABAergic and sedative properties that can produce additive CNS depression when combined with quetiapine. The combination may... |
The full quetiapine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common quetiapine questions.
Quick answers drawn from the tables above.
What interacts with Quetiapine?
In the NutriStack database, Quetiapine has 5 documented interactions. The most notable include St. John's Wort, Cannabis (THC-Dominant), Alcohol, Melatonin, and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Quetiapine?
Quetiapine is flagged against 2 substances in the database, including St. John's Wort and Cannabis (THC-Dominant). These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Quetiapine?
NutriStack classifies the St. John's Wort and Quetiapine pairing as contraindicated: St. John's Wort is a potent CYP3A4 inducer that can reduce quetiapine plasma concentrations by up to 80%, essentially rendering the medication ineffective. The... Do NOT take St. John's Wort with quetiapine. This combination is contraindicated due to the risk of complete loss of antipsychotic efficacy. If you... Always confirm with your prescriber.
Check your whole stack
See how quetiapine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.