Medication·Interactions·Reviewed June 9, 2026
Ranolazine interactions.
Ranolazine has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Ranolazine at a glance.
A quick, data-grounded summary. The full tables are below.
Ranolazine has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with ranolazine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort is a clinically important inducer of CYP3A4 and P-glycoprotein. Ranolazine is extensively metabolized by CYP3A and is also linked to... |
| Magnesium Glycinate | Synergy | Ranolazine can prolong the QT interval, and torsades risk rises when magnesium is low. Maintaining normal magnesium helps stabilize repolarization... details → |
| Potassium | Synergy | Ranolazine usually causes modest QT prolongation, but torsades de pointes has been reported when risk factors stack. Low potassium is a major... details → |
The full ranolazine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ranolazine questions.
Quick answers drawn from the tables above.
What interacts with Ranolazine?
In the NutriStack database, Ranolazine has 3 documented interactions. The most notable include St. John's Wort, Magnesium Glycinate, and Potassium. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Ranolazine?
Ranolazine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Ranolazine?
NutriStack classifies the St. John's Wort and Ranolazine pairing as conflict: St. John's Wort is a clinically important inducer of CYP3A4 and P-glycoprotein. Ranolazine is extensively metabolized by CYP3A and is also linked to... Avoid St. John's Wort while taking ranolazine. If you have already combined them, tell your prescriber, especially if angina, exercise tolerance, or... Always confirm with your prescriber.
Check your whole stack
See how ranolazine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.