Medication·Interactions·Reviewed June 9, 2026
Rasagiline interactions.
Rasagiline has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Rasagiline at a glance.
A quick, data-grounded summary. The full tables are below.
Rasagiline has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with rasagiline.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP can increase serotonin synthesis and is unsafe with MAO-inhibiting therapy. |
| L-Tryptophan | Contraindicated | L-Tryptophan supplementation increases serotonin precursor availability during MAO-B inhibitor therapy. |
| St. John's Wort | Contraindicated | St. John's Wort is listed among contraindicated products with rasagiline because of serotonin syndrome risk. |
| Rhodiola Rosea | Caution | Rhodiola may have stimulant or monoaminergic effects that could add to MAO-B inhibition. |
The full rasagiline profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common rasagiline questions.
Quick answers drawn from the tables above.
What interacts with Rasagiline?
In the NutriStack database, Rasagiline has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Rhodiola Rosea. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Rasagiline?
Rasagiline is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Rasagiline?
NutriStack classifies the 5-HTP and Rasagiline pairing as contraindicated: 5-HTP can increase serotonin synthesis and is unsafe with MAO-inhibiting therapy. Avoid 5-HTP while taking rasagiline. Always confirm with your prescriber.
Check your whole stack
See how rasagiline fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.