Medication·Interactions·Reviewed June 9, 2026
Risperidone interactions.
Risperidone has 6 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Risperidone at a glance.
A quick, data-grounded summary. The full tables are below.
Risperidone has 6 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with risperidone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Cannabis (THC-Dominant) | Conflict | THC-dominant cannabis can interfere with risperidone's relapse-prevention role in psychosis. Continued cannabis use in people with psychotic... details → |
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4, which metabolizes risperidone. Reduced risperidone levels can cause psychotic relapse. |
| Alcohol | Caution | Alcohol can increase risperidone-related drowsiness, slowed thinking, dizziness, and impaired coordination. Even when risperidone is less sedating... details → |
| Fish Oil | Synergy | Fish oil, as a source of omega-3 polyunsaturated fatty acids, has been studied as an adjunct in recent-onset psychosis patients treated with... details → |
| Methylfolate | Synergy | Methylfolate has been studied as an adjunct in medicated schizophrenia patients with residual symptoms. Benefits appear selective and may depend on... details → |
| NAC | Synergy | NAC has human trial evidence as an adjunct to risperidone for negative symptoms of schizophrenia. The effect is not immediate and does not replace... details → |
The full risperidone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common risperidone questions.
Quick answers drawn from the tables above.
What interacts with Risperidone?
In the NutriStack database, Risperidone has 6 documented interactions. The most notable include Cannabis (THC-Dominant), St. John's Wort, Alcohol, Fish Oil, and Methylfolate. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Risperidone?
Risperidone is flagged against 2 substances in the database, including Cannabis (THC-Dominant) and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Cannabis (THC-Dominant) with Risperidone?
NutriStack classifies the Cannabis (THC-Dominant) and Risperidone pairing as conflict: THC-dominant cannabis can interfere with risperidone's relapse-prevention role in psychosis. Continued cannabis use in people with psychotic disorders is linked with... Avoid THC-dominant cannabis while taking risperidone for psychosis or mood stabilization. If you are using cannabis, tell your prescriber so they... Always confirm with your prescriber.
Check your whole stack
See how risperidone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.