Medication·Interactions·Reviewed June 9, 2026
Rizatriptan interactions.
Rizatriptan has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Rizatriptan at a glance.
A quick, data-grounded summary. The full tables are below.
Rizatriptan has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with rizatriptan.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| MDMA | Contraindicated | MDMA causes large serotonin release and can trigger severe serotonin toxicity and hyperthermia. Rizatriptan is a serotonin receptor agonist, so... details → |
| 5-HTP | Caution | 5-HTP is a serotonin precursor, and rizatriptan is a 5-HT1B/1D receptor agonist. Direct case evidence for this exact pair is limited, but the... |
| St. John's Wort | Caution | St. John's wort has serotonergic antidepressant activity and has documented interaction concerns with antidepressant drugs. Rizatriptan is a... details → |
The full rizatriptan profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common rizatriptan questions.
Quick answers drawn from the tables above.
What interacts with Rizatriptan?
In the NutriStack database, Rizatriptan has 3 documented interactions. The most notable include MDMA, 5-HTP, and St. John's Wort. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Rizatriptan?
Rizatriptan is flagged against 1 substance in the database, including MDMA. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take MDMA with Rizatriptan?
NutriStack classifies the MDMA and Rizatriptan pairing as contraindicated: MDMA causes large serotonin release and can trigger severe serotonin toxicity and hyperthermia. Rizatriptan is a serotonin receptor agonist, so taking it around MDMA... Do not combine MDMA with rizatriptan. If MDMA was used, avoid taking rizatriptan and seek medical advice for severe headache, chest pain, high... Always confirm with your prescriber.
Check your whole stack
See how rizatriptan fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.