Medication·Interactions·Reviewed June 9, 2026
Roflumilast interactions.
Roflumilast has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Roflumilast at a glance.
A quick, data-grounded summary. The full tables are below.
Roflumilast has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with roflumilast.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can induce CYP3A4 and may reduce roflumilast exposure, potentially decreasing COPD exacerbation prevention. |
| Berberine | Caution | Berberine may affect CYP enzymes and P-glycoprotein, creating theoretical exposure changes for roflumilast. |
| Green Tea Extract | Caution | Caffeinated green tea extract may compound roflumilast-associated insomnia, anxiety, tremor, or appetite suppression. |
| Quercetin | Caution | Quercetin can inhibit some CYP enzymes and transporters in vitro, which could make roflumilast tolerability less predictable. |
The full roflumilast profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common roflumilast questions.
Quick answers drawn from the tables above.
What interacts with Roflumilast?
In the NutriStack database, Roflumilast has 4 documented interactions. The most notable include St. John's Wort, Berberine, Green Tea Extract, and Quercetin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Roflumilast?
Roflumilast is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Roflumilast?
NutriStack classifies the St. John's Wort and Roflumilast pairing as conflict: St. John's Wort can induce CYP3A4 and may reduce roflumilast exposure, potentially decreasing COPD exacerbation prevention. Avoid St. John's Wort unless the prescriber specifically approves and monitors clinical response. Always confirm with your prescriber.
Check your whole stack
See how roflumilast fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.