Medication·Interactions·Reviewed June 9, 2026
Salmeterol/Fluticasone interactions.
Salmeterol/Fluticasone has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Salmeterol/Fluticasone at a glance.
A quick, data-grounded summary. The full tables are below.
Salmeterol/Fluticasone has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with salmeterol/fluticasone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can induce CYP3A4 and may lower exposure to CYP3A4 substrates, potentially making controller response less predictable. |
| Green Tea Extract | Caution | Caffeinated green tea extract may add to salmeterol-related tremor, palpitations, and insomnia. |
| Magnesium Glycinate | Synergy | Magnesium repletion can support normal airway and cardiac physiology when deficiency is present. |
| Potassium | Synergy | Beta-2 agonists can lower serum potassium at high exposure, and correcting true hypokalemia reduces arrhythmia risk. |
The full salmeterol/fluticasone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common salmeterol/fluticasone questions.
Quick answers drawn from the tables above.
What interacts with Salmeterol/Fluticasone?
In the NutriStack database, Salmeterol/Fluticasone has 4 documented interactions. The most notable include St. John's Wort, Green Tea Extract, Magnesium Glycinate, and Potassium. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Salmeterol/Fluticasone?
Salmeterol/Fluticasone is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Salmeterol/Fluticasone?
NutriStack classifies the St. John's Wort and Salmeterol/Fluticasone pairing as conflict: St. John's Wort can induce CYP3A4 and may lower exposure to CYP3A4 substrates, potentially making controller response less predictable. Avoid unsupervised St. John's Wort in patients relying on stable inhaled controller therapy; discuss mood treatment alternatives with a clinician. Always confirm with your prescriber.
Check your whole stack
See how salmeterol/fluticasone fits your supplements.
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