Medication·Interactions·Reviewed June 9, 2026
Selegiline interactions.
Selegiline has 5 documented interactions in the NutriStack database, including 4 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Selegiline at a glance.
A quick, data-grounded summary. The full tables are below.
Selegiline has 5 documented interactions in the NutriStack database, including 4 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with selegiline.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP increases serotonin synthesis while Selegiline reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and... details → |
| L-Tryptophan | Contraindicated | L-Tryptophan feeds serotonin synthesis while Selegiline reduces serotonin breakdown, increasing risk of serotonin syndrome. details → |
| St. John's Wort | Contraindicated | St. John's Wort is explicitly contraindicated with selegiline transdermal labeling and is unsafe with MAOI therapy because of serotonergic effects. |
| Tyramine / High-Tyramine Foods | Contraindicated | Selegiline can act as a monoamine oxidase inhibitor depending on formulation and dose. Systemic or higher-dose MAOI exposure can reduce tyramine... details → |
| Rhodiola Rosea | Caution | Rhodiola is promoted for stimulant and monoaminergic effects. Combining it with MAO-B inhibition may increase agitation, insomnia, blood pressure,... |
The full selegiline profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common selegiline questions.
Quick answers drawn from the tables above.
What interacts with Selegiline?
In the NutriStack database, Selegiline has 5 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, Tyramine / High-Tyramine Foods, and Rhodiola Rosea. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Selegiline?
Selegiline is flagged against 4 substances in the database, including 5-HTP, L-Tryptophan, St. John's Wort, and Tyramine / High-Tyramine Foods. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Selegiline?
NutriStack classifies the 5-HTP and Selegiline pairing as contraindicated: 5-HTP increases serotonin synthesis while Selegiline reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and serotonin syndrome. Do NOT combine 5-HTP with Selegiline. Use only if the prescriber managing Selegiline explicitly directs it and provides washout instructions. Always confirm with your prescriber.
Check your whole stack
See how selegiline fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.