Medication·Interactions·Reviewed June 9, 2026
Silodosin interactions.
Silodosin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Silodosin at a glance.
A quick, data-grounded summary. The full tables are below.
Silodosin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with silodosin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can induce CYP3A4 and P-glycoprotein and may reduce silodosin exposure. |
| L-Citrulline | Caution | L-citrulline can increase nitric oxide availability and may add to silodosin-related dizziness or orthostatic hypotension. |
| Quercetin | Caution | High-dose quercetin may inhibit CYP3A4 or P-glycoprotein and could increase silodosin exposure. |
| Saw Palmetto | Synergy | Saw palmetto is often used for urinary symptoms and may overlap with silodosin goals, but evidence is less consistent than prescription alpha... |
The full silodosin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common silodosin questions.
Quick answers drawn from the tables above.
What interacts with Silodosin?
In the NutriStack database, Silodosin has 4 documented interactions. The most notable include St. John's Wort, L-Citrulline, Quercetin, and Saw Palmetto. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Silodosin?
Silodosin is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Silodosin?
NutriStack classifies the St. John's Wort and Silodosin pairing as conflict: St. John's Wort can induce CYP3A4 and P-glycoprotein and may reduce silodosin exposure. Avoid unsupervised use if urinary symptom control depends on silodosin. Always confirm with your prescriber.
Check your whole stack
See how silodosin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.