Medication·Interactions·Reviewed June 9, 2026
Solifenacin interactions.
Solifenacin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Solifenacin at a glance.
A quick, data-grounded summary. The full tables are below.
Solifenacin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with solifenacin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can induce CYP3A4 and may reduce solifenacin exposure, decreasing bladder symptom control. |
| Melatonin | Caution | Melatonin may add to solifenacin-associated somnolence or dizziness. |
| Potassium | Caution | Antimuscarinic slowing of gastrointestinal transit may increase mucosal injury risk from solid oral potassium products. |
| Quercetin | Caution | High-dose quercetin may inhibit CYP3A4 or transporters and could increase solifenacin adverse effects. |
The full solifenacin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common solifenacin questions.
Quick answers drawn from the tables above.
What interacts with Solifenacin?
In the NutriStack database, Solifenacin has 4 documented interactions. The most notable include St. John's Wort, Melatonin, Potassium, and Quercetin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Solifenacin?
Solifenacin is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Solifenacin?
NutriStack classifies the St. John's Wort and Solifenacin pairing as conflict: St. John's Wort can induce CYP3A4 and may reduce solifenacin exposure, decreasing bladder symptom control. Avoid starting or stopping St. John's Wort without discussing symptom monitoring and alternatives. Always confirm with your prescriber.
Check your whole stack
See how solifenacin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.