Medication·Interactions·Reviewed June 9, 2026
Sumatriptan interactions.
Sumatriptan has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Sumatriptan at a glance.
A quick, data-grounded summary. The full tables are below.
Sumatriptan has 3 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with sumatriptan.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| MDMA | Contraindicated | MDMA causes a large serotonin release and can produce severe serotonin toxicity and hyperthermia. Sumatriptan is a serotonin receptor agonist, so... details → |
| 5-HTP | Caution | 5-HTP is a direct serotonin precursor, and sumatriptan is a serotonin receptor agonist used for migraine attacks. Direct case evidence for this... |
| St. John's Wort | Caution | St. John's wort has serotonergic antidepressant activity and has been linked to clinically important interactions with antidepressant drugs.... details → |
The full sumatriptan profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common sumatriptan questions.
Quick answers drawn from the tables above.
What interacts with Sumatriptan?
In the NutriStack database, Sumatriptan has 3 documented interactions. The most notable include MDMA, 5-HTP, and St. John's Wort. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Sumatriptan?
Sumatriptan is flagged against 1 substance in the database, including MDMA. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take MDMA with Sumatriptan?
NutriStack classifies the MDMA and Sumatriptan pairing as contraindicated: MDMA causes a large serotonin release and can produce severe serotonin toxicity and hyperthermia. Sumatriptan is a serotonin receptor agonist, so using it around MDMA... Do not combine MDMA with sumatriptan. If MDMA was used, avoid taking sumatriptan and seek medical advice for severe headache, chest pain, high... Always confirm with your prescriber.
Check your whole stack
See how sumatriptan fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.