Medication·Interactions·Reviewed June 9, 2026
Testosterone interactions.
Testosterone has 11 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Testosterone at a glance.
A quick, data-grounded summary. The full tables are below.
Testosterone has 11 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with testosterone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ashwagandha | Caution | Ashwagandha (Withania somnifera) modestly raises testosterone and LH in men with infertility or stress and can also raise T4 and lower TSH. Adding... details → |
| Boron | Caution | In a small trial, daily boron 10 mg raised free testosterone and modestly lowered estradiol in healthy men over one week. The clinical impact on top... |
| DHEA | Caution | DHEA is a precursor hormone that can be converted to both testosterone and estrogen. When combined with exogenous testosterone therapy, DHEA... details → |
| DIM | Caution | DIM (diindolylmethane) modifies estrogen metabolism by activating CYP1A1 and CYP1A2 enzymes, shifting estrogen metabolism toward the... |
| Fenugreek | Caution | Fenugreek extracts (especially standardized products like Furosap) modestly raise free testosterone in men in small clinical trials. Layering... details → |
| Maca Root | Caution | Maca (Lepidium meyenii) has shown benefits for libido and sexual function in small trials but does not raise serum testosterone. It is generally... |
| Saw Palmetto | Caution | Saw palmetto is often marketed for androgen and prostate symptoms, but clinically meaningful hormone-lowering or BPH symptom benefit is not well... details → |
| Tongkat Ali | Caution | Eurycoma longifolia (tongkat ali) significantly raises serum total testosterone in healthy and hypogonadal men in a meta-analysis of five RCTs.... details → |
| Tribulus Terrestris | Caution | Tribulus terrestris is widely marketed as a testosterone booster, but systematic reviews and meta-analyses generally find no consistent effect on... details → |
| Vitamin D3 | Synergy | Vitamin D deficiency is associated with lower testosterone in observational studies, but a high-quality RCT showed that 20,000 IU/week vitamin D3... details → |
| Zinc | Synergy | Zinc is essential for testosterone synthesis and metabolism. It inhibits aromatase (preventing testosterone-to-estrogen conversion) and modulates... details → |
The full testosterone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common testosterone questions.
Quick answers drawn from the tables above.
What interacts with Testosterone?
In the NutriStack database, Testosterone has 11 documented interactions. The most notable include Ashwagandha, Boron, DHEA, DIM, and Fenugreek. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Ashwagandha with Testosterone?
NutriStack classifies the Ashwagandha and Testosterone pairing as caution: Ashwagandha (Withania somnifera) modestly raises testosterone and LH in men with infertility or stress and can also raise T4 and lower TSH. Adding it to prescribed... Use ashwagandha cautiously while on prescribed testosterone. If you take both, monitor hematocrit, PSA, mood, and a TSH check every 6-12 months... Always confirm with your prescriber.
Check your whole stack
See how testosterone fits your supplements.
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