Medication·Interactions·Reviewed June 9, 2026
Ticagrelor interactions.
Ticagrelor has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Ticagrelor at a glance.
A quick, data-grounded summary. The full tables are below.
Ticagrelor has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with ticagrelor.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | Ticagrelor is metabolised by CYP3A4 and is a P-glycoprotein substrate. St. John's wort potently induces both, and the model CYP3A4/P-gp inducer... details → |
| Fish Oil | Caution | Fish oil's omega-3 fatty acids reduce platelet thromboxane A2 generation and modestly prolong bleeding time. Added to ticagrelor's P2Y12 inhibition,... |
| Garlic Extract | Caution | Concentrated garlic supplements inhibit platelet aggregation. Combined with ticagrelor's P2Y12 inhibition, garlic supplements stack antiplatelet... |
| Ginkgo Biloba | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to ticagrelor's reversible P2Y12 inhibition, the antiplatelet... details → |
| Nattokinase | Caution | Nattokinase can add fibrinolytic and anticoagulant effects to ticagrelor's potent antiplatelet action. Human studies show nattokinase lowers... |
The full ticagrelor profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ticagrelor questions.
Quick answers drawn from the tables above.
What interacts with Ticagrelor?
In the NutriStack database, Ticagrelor has 5 documented interactions. The most notable include St. John's Wort, Fish Oil, Garlic Extract, Ginkgo Biloba, and Nattokinase. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Ticagrelor?
Ticagrelor is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Ticagrelor?
NutriStack classifies the St. John's Wort and Ticagrelor pairing as conflict: Ticagrelor is metabolised by CYP3A4 and is a P-glycoprotein substrate. St. John's wort potently induces both, and the model CYP3A4/P-gp inducer rifampin reduces... Avoid St. John's wort while on ticagrelor. If you have been taking both, stop the St. John's wort and tell your prescriber so antiplatelet adequacy... Always confirm with your prescriber.
Check your whole stack
See how ticagrelor fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.