Medication·Interactions·Reviewed June 9, 2026
Tolterodine interactions.
Tolterodine has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Tolterodine at a glance.
A quick, data-grounded summary. The full tables are below.
Tolterodine has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with tolterodine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort may induce CYP3A4 and reduce tolterodine exposure, lowering symptom control. |
| Melatonin | Caution | Melatonin may add to tolterodine-associated somnolence or dizziness. |
| Potassium | Caution | Antimuscarinic slowing of gastrointestinal transit may increase mucosal injury risk from solid potassium products. |
| Quercetin | Caution | High-dose quercetin may inhibit CYP3A4 or transporters, potentially increasing tolterodine exposure in some patients. |
The full tolterodine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common tolterodine questions.
Quick answers drawn from the tables above.
What interacts with Tolterodine?
In the NutriStack database, Tolterodine has 4 documented interactions. The most notable include St. John's Wort, Melatonin, Potassium, and Quercetin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Tolterodine?
Tolterodine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Tolterodine?
NutriStack classifies the St. John's Wort and Tolterodine pairing as conflict: St. John's Wort may induce CYP3A4 and reduce tolterodine exposure, lowering symptom control. Avoid starting or stopping without monitoring overactive bladder symptoms and adverse effects. Always confirm with your prescriber.
Check your whole stack
See how tolterodine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.