Medication·Interactions·Reviewed June 9, 2026
Tranylcypromine interactions.
Tranylcypromine has 5 documented interactions in the NutriStack database, including 5 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Tranylcypromine at a glance.
A quick, data-grounded summary. The full tables are below.
Tranylcypromine has 5 documented interactions in the NutriStack database, including 5 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with tranylcypromine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP increases serotonin synthesis while Tranylcypromine reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and... details → |
| L-Tryptophan | Contraindicated | L-Tryptophan feeds serotonin synthesis while Tranylcypromine reduces serotonin breakdown, increasing risk of serotonin syndrome. details → |
| St. John's Wort | Contraindicated | St. John's Wort has serotonergic effects and is unsafe with irreversible MAOIs. |
| Tyramine / High-Tyramine Foods | Contraindicated | Tranylcypromine is an irreversible MAOI that can sharply reduce tyramine breakdown. High-tyramine foods can then trigger sudden, severe... details → |
| Rhodiola Rosea | Conflict | Rhodiola may have stimulant or monoaminergic effects that are poorly predictable during nonselective MAO inhibition. |
The full tranylcypromine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common tranylcypromine questions.
Quick answers drawn from the tables above.
What interacts with Tranylcypromine?
In the NutriStack database, Tranylcypromine has 5 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, Tyramine / High-Tyramine Foods, and Rhodiola Rosea. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Tranylcypromine?
Tranylcypromine is flagged against 5 substances in the database, including 5-HTP, L-Tryptophan, St. John's Wort, Tyramine / High-Tyramine Foods, and Rhodiola Rosea. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Tranylcypromine?
NutriStack classifies the 5-HTP and Tranylcypromine pairing as contraindicated: 5-HTP increases serotonin synthesis while Tranylcypromine reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and serotonin syndrome. Do NOT combine 5-HTP with Tranylcypromine. Use only if the prescriber managing Tranylcypromine explicitly directs it and provides washout... Always confirm with your prescriber.
Check your whole stack
See how tranylcypromine fits your supplements.
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