Medication·Interactions·Reviewed June 9, 2026
Verapamil interactions.
Verapamil has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Verapamil at a glance.
A quick, data-grounded summary. The full tables are below.
Verapamil has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with verapamil.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4, the primary enzyme metabolizing verapamil. This can reduce verapamil levels by 40-80%, leading to loss of heart... details → |
| Berberine | Caution | Verapamil is both a CYP3A4 substrate and a potent P-glycoprotein inhibitor, and berberine inhibits both CYP3A4 and P-gp. Combining the two raises... details → |
| Magnesium Glycinate | Caution | Both verapamil and magnesium block calcium channels. Combined use can cause excessive bradycardia, hypotension, and AV conduction delay. details → |
| Quercetin | Caution | In rabbits, quercetin roughly doubled both the Cmax and AUC of verapamil by inhibiting CYP3A4 and P-glycoprotein. Verapamil already has a narrow... |
| Taurine | Caution | Taurine lowers systolic and diastolic blood pressure by about 3-4 mmHg in meta-analysis and has direct heart-rate-lowering effects. Combined with... details → |
The full verapamil profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common verapamil questions.
Quick answers drawn from the tables above.
What interacts with Verapamil?
In the NutriStack database, Verapamil has 5 documented interactions. The most notable include St. John's Wort, Berberine, Magnesium Glycinate, Quercetin, and Taurine. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Verapamil?
Verapamil is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Verapamil?
NutriStack classifies the St. John's Wort and Verapamil pairing as conflict: St. John's Wort induces CYP3A4, the primary enzyme metabolizing verapamil. This can reduce verapamil levels by 40-80%, leading to loss of heart rate/blood pressure... Avoid St. John's Wort with verapamil. Loss of rate control can be dangerous in atrial fibrillation patients. Always confirm with your prescriber.
Check your whole stack
See how verapamil fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.