Medication·Interactions·Reviewed June 9, 2026
Vilazodone interactions.
Vilazodone has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Vilazodone at a glance.
A quick, data-grounded summary. The full tables are below.
Vilazodone has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with vilazodone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP can increase serotonin production and may precipitate serotonin syndrome with vilazodone. |
| L-Tryptophan | Contraindicated | L-Tryptophan supplements can increase serotonin synthesis and add to vilazodone's serotonergic effect. |
| St. John's Wort | Contraindicated | St. John's Wort has serotonergic effects and can also induce CYP3A4, making both toxicity and loss of antidepressant control possible. |
| Ginkgo Biloba | Caution | Vilazodone can increase bleeding risk through platelet serotonin effects; ginkgo may also increase bleeding tendency in susceptible patients. |
The full vilazodone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common vilazodone questions.
Quick answers drawn from the tables above.
What interacts with Vilazodone?
In the NutriStack database, Vilazodone has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Vilazodone?
Vilazodone is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Vilazodone?
NutriStack classifies the 5-HTP and Vilazodone pairing as contraindicated: 5-HTP can increase serotonin production and may precipitate serotonin syndrome with vilazodone. Avoid 5-HTP during vilazodone treatment. Always confirm with your prescriber.
Check your whole stack
See how vilazodone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.