Medication·Interactions·Reviewed June 9, 2026
Vortioxetine interactions.
Vortioxetine has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Vortioxetine at a glance.
A quick, data-grounded summary. The full tables are below.
Vortioxetine has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with vortioxetine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP is a direct serotonin precursor. Combining it with vortioxetine can produce excessive serotonergic activity and serotonin syndrome. |
| L-Tryptophan | Contraindicated | Supplemental L-Tryptophan can increase serotonin synthesis and raise serotonin-toxicity risk with vortioxetine. |
| St. John's Wort | Contraindicated | St. John's Wort has serotonergic activity and can interact unpredictably with antidepressants. |
| Fish Oil | Caution | Vortioxetine may increase bleeding tendency through serotonin effects on platelets. High-dose fish oil can have mild antiplatelet effects. |
The full vortioxetine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common vortioxetine questions.
Quick answers drawn from the tables above.
What interacts with Vortioxetine?
In the NutriStack database, Vortioxetine has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Fish Oil. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Vortioxetine?
Vortioxetine is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Vortioxetine?
NutriStack classifies the 5-HTP and Vortioxetine pairing as contraindicated: 5-HTP is a direct serotonin precursor. Combining it with vortioxetine can produce excessive serotonergic activity and serotonin syndrome. Avoid 5-HTP while taking vortioxetine unless specifically directed by a specialist; seek urgent care for fever, agitation, sweating, tremor, clonus,... Always confirm with your prescriber.
Check your whole stack
See how vortioxetine fits your supplements.
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