Medication·Interactions·Reviewed June 9, 2026
Zolpidem interactions.
Zolpidem has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Zolpidem at a glance.
A quick, data-grounded summary. The full tables are below.
Zolpidem has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with zolpidem.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol adds to zolpidem's hypnotic and psychomotor-impairing effects. Controlled testing showed both zolpidem and alcohol impaired cognitive and... details → |
| Melatonin | Caution | Both zolpidem and melatonin promote sleep through different mechanisms. Combined use may cause excessive sedation but is sometimes used clinically... details → |
| St. John's Wort | Caution | St. John's Wort can induce CYP3A4 and P-glycoprotein, while zolpidem is partly cleared through CYP3A-mediated metabolism. The combination may reduce... |
| Valerian Root | Caution | Both zolpidem and valerian act on GABA-A receptors. Combined use can cause excessive CNS depression, over-sedation, and next-day impairment. details → |
The full zolpidem profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common zolpidem questions.
Quick answers drawn from the tables above.
What interacts with Zolpidem?
In the NutriStack database, Zolpidem has 4 documented interactions. The most notable include Alcohol, Melatonin, St. John's Wort, and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Zolpidem?
Zolpidem is flagged against 1 substance in the database, including Alcohol. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Zolpidem?
NutriStack classifies the Alcohol and Zolpidem pairing as contraindicated: Alcohol adds to zolpidem's hypnotic and psychomotor-impairing effects. Controlled testing showed both zolpidem and alcohol impaired cognitive and motor performance, and... Do not drink alcohol on nights you take zolpidem. Do not take zolpidem after drinking, even if you feel awake. Seek help if sleepwalking,... Always confirm with your prescriber.
Check your whole stack
See how zolpidem fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.