Supplement·Interactions·Reviewed June 9, 2026
Apigenin interactions.
Apigenin has 8 documented interactions in the NutriStack database: 1 that need timing or caution and 7 that work synergistically. The full list, with what each pairing does, is below.
Apigenin at a glance.
A quick, data-grounded summary. The full table is below.
Apigenin has 8 documented interactions in the NutriStack database: 1 that need timing or caution and 7 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with apigenin.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Diazepam | Caution | Apigenin has benzodiazepine-receptor and GABA(A)-modulating activity in preclinical studies. One receptor study specifically found that apigenin... |
| Magnesium Citrate | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Magnesium Glycinate | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Magnesium L-Threonate | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Magnesium Malate | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Magnesium Taurate | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Melatonin | Synergy | Apigenin is a natural flavonoid that binds GABA-A benzodiazepine receptors, promoting sleep through a different mechanism than melatonin. |
| NMN | Synergy | NMN raises NAD+ substrate; apigenin inhibits CD38, the enzyme that consumes NAD+. Combined effect on whole blood NAD+ may be additive. |
The full apigenin profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common apigenin questions.
Quick answers drawn from the table above.
What interacts with Apigenin?
In the NutriStack database, Apigenin has 8 documented interactions with other supplements and medications. The most notable include Diazepam, Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, and Magnesium Malate.
What works well with Apigenin?
Apigenin pairs synergistically with Magnesium Citrate, Magnesium Glycinate, Magnesium L-Threonate, Magnesium Malate, and Magnesium Taurate in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Apigenin with Diazepam?
NutriStack classifies the Apigenin and Diazepam pairing as caution: Apigenin has benzodiazepine-receptor and GABA(A)-modulating activity in preclinical studies. One receptor study specifically found that apigenin enhanced diazepam's... Use apigenin cautiously if you take diazepam, especially when starting either product or increasing doses. Avoid alcohol and other sedatives, and do...
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