Supplement·Interactions·Reviewed June 9, 2026
Black Seed Oil interactions.
Black Seed Oil has 6 documented interactions in the NutriStack database: 5 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Black Seed Oil at a glance.
A quick, data-grounded summary. The full table is below.
Black Seed Oil has 6 documented interactions in the NutriStack database: 5 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with black seed oil.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Both lower blood glucose, so combined use can produce additive hypoglycemic effects, particularly in people also taking diabetes medications. details → |
| Fenugreek | Caution | Both supplements are well-documented oral hypoglycemics in human trials. Taken concurrently, especially alongside antidiabetic medication... |
| Fish Oil | Caution | Both can modestly lower blood pressure and affect platelet function, so combining them may produce additive reductions in blood pressure and a small... |
| Garlic Extract | Caution | Two supplements with reproducible antihypertensive effects in human trials. Combined, the blood-pressure reduction can be additive, which is helpful... details → |
| Warfarin | Caution | Thymoquinone, the main bioactive in black seed oil (Nigella sativa), is a competitive inhibitor of CYP2C9-mediated warfarin 7-hydroxylation.... |
| Turmeric/Curcumin | Synergy | Both are anti-inflammatory and antioxidant agents that have shown complementary metabolic benefits when studied together, including improved... |
The full black seed oil profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common black seed oil questions.
Quick answers drawn from the table above.
What interacts with Black Seed Oil?
In the NutriStack database, Black Seed Oil has 6 documented interactions with other supplements and medications. The most notable include Berberine, Fenugreek, Fish Oil, Garlic Extract, and Warfarin.
What works well with Black Seed Oil?
Black Seed Oil pairs synergistically with Turmeric/Curcumin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Black Seed Oil with Berberine?
NutriStack classifies the Black Seed Oil and Berberine pairing as caution: Both lower blood glucose, so combined use can produce additive hypoglycemic effects, particularly in people also taking diabetes medications. Monitor blood glucose more closely when combining. Watch for symptoms of hypoglycemia (shakiness, sweating, confusion) and coordinate with a...
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