Supplement·Interactions·Reviewed June 9, 2026
Citrulline Malate interactions.
Citrulline Malate has 4 documented interactions in the NutriStack database: 1 to avoid or watch closely, 1 that need timing or caution, and 2 that work synergistically. The full list, with what each pairing does, is below.
Citrulline Malate at a glance.
A quick, data-grounded summary. The full table is below.
Citrulline Malate has 4 documented interactions in the NutriStack database: 1 to avoid or watch closely, 1 that need timing or caution, and 2 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with citrulline malate.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| L-Citrulline | Conflict | Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects. |
| Garlic Extract | Caution | Both may lower blood pressure through vascular mechanisms. |
| Creatine | Synergy | Creatine and citrulline target different performance mechanisms. |
| Taurine | Synergy | Taurine may complement endurance, osmotic balance, and excitation-contraction support. |
The full citrulline malate profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common citrulline malate questions.
Quick answers drawn from the table above.
What interacts with Citrulline Malate?
In the NutriStack database, Citrulline Malate has 4 documented interactions with other supplements and medications. The most notable include L-Citrulline, Garlic Extract, Creatine, and Taurine.
What should you not take with Citrulline Malate?
Citrulline Malate is flagged against 1 substance in the database, including L-Citrulline. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Citrulline Malate?
Citrulline Malate pairs synergistically with Creatine and Taurine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Citrulline Malate with L-Citrulline?
NutriStack classifies the Citrulline Malate and L-Citrulline pairing as conflict: Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects. Count total citrulline from all products and reduce doses if stacking.
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