Supplement·Interactions·Reviewed June 9, 2026
Coenzyme Q10 interactions.
Coenzyme Q10 has 56 documented interactions in the NutriStack database: 9 that need timing or caution and 47 that work synergistically. The full list, with what each pairing does, is below.
In short
Coenzyme Q10 at a glance.
A quick, data-grounded summary. The full table is below.
Coenzyme Q10 has 56 documented interactions in the NutriStack database: 9 that need timing or caution and 47 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with coenzyme q10.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Berberine may inhibit mitochondrial Complex I, similar to metformin. CoQ10 supplementation may help offset potential mitochondrial effects. |
| Berberine HCl | Caution | Berberine HCl may inhibit mitochondrial Complex I, similar to metformin. CoQ10 supplementation may help offset potential mitochondrial effects. |
| Candesartan | Caution | Coenzyme Q10 has shown a mild blood-pressure-lowering effect in some trials. When combined with candesartan, the antihypertensive effect could be... |
| Gemfibrozil | Caution | Gemfibrozil, like statins and other fibrates, can lower circulating coenzyme Q10 (ubiquinone) concentrations and is associated with muscle-related... |
| Metoprolol | Caution | Beta-blockers including metoprolol may reduce endogenous CoQ10 levels by inhibiting CoQ10-dependent mitochondrial enzymes. Some studies suggest... |
| MitoQ (Mitoquinone) | Caution | MitoQ is a mitochondria-targeted ubiquinone derivative and Coenzyme Q10 (ubiquinone/ubiquinol) is the native molecule. They are pharmacologically... |
| Nebivolol | Caution | Beta-blockers, including nebivolol, can inhibit CoQ10-dependent enzymes and may lower endogenous CoQ10 levels (a recognized class effect, best... |
| Warfarin | Caution | Coenzyme Q10 (ubiquinone) is structurally similar to vitamin K and may reduce warfarin's anticoagulant effect in some patients. Case reports... details → |
| Fenofibrate | Timing Sensitive | Fibrates, like statins, may modestly lower endogenous coenzyme Q10 (ubiquinone) levels, and myopathy risk rises when fenofibrate is combined with a... |
| Acetyl-L-Carnitine | Synergy | Both support mitochondrial energy production through complementary mechanisms; combined use is common in cardiovascular and neurological contexts. |
| Alpha-Lipoic Acid | Synergy | Both support mitochondrial function. CoQ10 is essential for the electron transport chain; ALA is a cofactor for mitochondrial dehydrogenases. |
| Amlodipine | Synergy | CoQ10 produces a small but consistent reduction in systolic blood pressure (about 3-5 mmHg) and improves endothelial function, complementing... details → |
| Atenolol | Synergy | Like other beta-blockers, atenolol inhibits mitochondrial CoQ10-dependent enzymes, contributing to fatigue and reduced exercise tolerance. CoQ10... details → |
| Atorvastatin | Synergy | Atorvastatin can lower circulating CoQ10 because cholesterol and CoQ10 synthesis share the mevalonate pathway. Lower CoQ10 is one proposed... details → |
| Bempedoic Acid | Synergy | Coenzyme Q10 (ubiquinone) is frequently used by patients on cholesterol-lowering therapy because statins deplete endogenous CoQ10 synthesis.... |
| Bergamot (Citrus Bergamia) Extract | Synergy | CoQ10 is often paired with lipid-lowering strategies to support mitochondrial function, though direct bergamot-CoQ10 outcome data are limited. |
| Bisoprolol | Synergy | Beta-blockers as a class inhibit mitochondrial CoQ10-dependent enzymes, contributing to fatigue and reduced exercise tolerance. CoQ10 100-200 mg/day... details → |
| Carvedilol | Synergy | Beta-blockers may reduce CoQ10 levels. CoQ10 supplementation is particularly relevant for carvedilol patients with heart failure, as CoQ10 supports... details → |
| Combined Oral Contraceptive | Synergy | Combined oral contraceptive use significantly decreases serum coenzyme Q10 levels in premenopausal women, mirroring the drop seen with statins.... details → |
| Cordyceps | Synergy | Both support mitochondrial energy production. Cordyceps increases ATP synthesis; CoQ10 is essential for the electron transport chain. |
| Elamipretide (SS-31) | Synergy | CoQ10 is often used in mitochondrial care, but it does not replace Forzinity or prove off-label benefit. |
| Enalapril | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A clinical study using CoQ10 as a... details → |
| Ergothioneine | Synergy | Both target mitochondrial function and oxidative stress through distinct routes, so co-supplementation may offer complementary mitochondrial... |
| Evening Primrose Oil | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Coenzyme Q10. |
| Evolocumab | Synergy | Coenzyme Q10 (ubiquinone) is sometimes used by patients on lipid-lowering therapy because of concerns about statin-associated muscle symptoms.... |
| Fish Oil | Synergy | CoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle. details → |
| Fish Oil Triple Strength | Synergy | CoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle. |
| Flaxseed Oil | Synergy | Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Coenzyme Q10. |
| Garlic Extract | Synergy | Aged garlic extract combined with coenzyme Q10 improved endothelial function and vascular elasticity in a randomized trial, with both agents... details → |
| Hawthorn (Crataegus) | Synergy | Both are used in cardiovascular support stacks, especially for cardiac energy and symptoms. |
| Humanin | Synergy | CoQ10 and humanin are both used in mitochondrial-health contexts, but humanin remains unapproved. |
| Krill Oil | Synergy | CoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle. |
| L-Carnitine | Synergy | The pair supports complementary stages of mitochondrial energy production, with L-Carnitine increasing fatty acid delivery into mitochondria and... |
| Lisinopril | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical... details → |
| Lovastatin | Synergy | Lovastatin can lower CoQ10 production by blocking the mevalonate pathway. CoQ10 depletion is a plausible contributor to statin-associated myalgia,... details → |
| MCT Oil | Synergy | MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Coenzyme Q10. |
| Metformin | Synergy | Metformin inhibits mitochondrial respiratory chain complex I, which is part of how it lowers hepatic glucose output but also contributes to lactate... |
| Nicotinamide Riboside | Synergy | NAD+ (replenished by NR) and coenzyme Q10 act at sequential points of the mitochondrial electron transport chain: NADH delivers electrons to Complex... |
| NMN | Synergy | NMN boosts NAD+ for mitochondrial enzymes; CoQ10 supports the electron transport chain. Comprehensive mitochondrial support for anti-aging. |
| Omega-7 | Synergy | Taking CoQ10 alongside an Omega-7 oil capsule provides the dietary lipid that CoQ10 absorption depends on. Pharmacology literature consistently... |
| Ox Bile | Synergy | Ox bile can increase the absorption of poorly bioavailable Coenzyme Q10 by improving its incorporation into bile-salt mixed micelles in the small... |
| PQQ | Synergy | Combined supplementation supports mitochondrial energy production and biogenesis, and the pair has been studied together in human cognitive function... |
| Pravastatin | Synergy | All statins reduce CoQ10 levels by inhibiting the mevalonate pathway. Pravastatin has lower myopathy risk but still depletes CoQ10. Supplementation... details → |
| Propranolol | Synergy | Propranolol is the strongest CoQ10-enzyme inhibitor among beta-blockers, which contributes to fatigue and exercise intolerance. CoQ10... details → |
| Ramipril | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical... details → |
| Red Yeast Rice | Synergy | CoQ10 is often paired with statin-like therapies because HMG-CoA reductase inhibition can reduce endogenous CoQ10 synthesis. |
| Rosuvastatin | Synergy | Statins inhibit HMG-CoA reductase, which is also upstream of CoQ10 synthesis in the mevalonate pathway. Rosuvastatin can reduce plasma CoQ10 by 40%.... details → |
| Selenium | Synergy | Adequate selenium status helps keep coenzyme Q10 in its active reduced form, and the pair together supports cardiac function more than either alone... details → |
| Shilajit | Synergy | Shilajit appears to enhance the mitochondrial action of CoQ10, with preclinical data showing greater ATP recovery and cellular energy production... |
| Simvastatin | Synergy | Simvastatin can reduce circulating CoQ10 by inhibiting the same pathway used to make cholesterol. CoQ10 supplementation has mixed but plausible... details → |
| Spermidine | Synergy | Spermidine improves mitochondrial autophagy (mitophagy) while CoQ10 supports the mitochondrial electron transport chain, a complementary... |
| Timolol Ophthalmic | Synergy | Timolol eye drops can produce systemic beta-blockade through nasolacrimal absorption, especially in older adults. Like systemic beta-blockers,... |
| Tocotrienols | Synergy | Both are fat-soluble cardiometabolic supplements often taken with meals. |
| Urolithin A | Synergy | Both support mitochondrial function through different roles: Urolithin A improves mitochondrial quality via mitophagy while CoQ10 supports the... |
| Vitamin B2 | Synergy | Riboflavin and coenzyme Q10 both support mitochondrial energy production and are used together for migraine prophylaxis, where their effects on the... |
| Vitamin E | Synergy | CoQ10 (ubiquinol form) regenerates vitamin E from its oxidized form in cell membranes, similar to how vitamin C regenerates vitamin E. |
Go deeper
The full coenzyme q10 profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common coenzyme q10 questions.
Quick answers drawn from the table above.
What interacts with Coenzyme Q10?
In the NutriStack database, Coenzyme Q10 has 56 documented interactions with other supplements and medications. The most notable include Berberine, Berberine HCl, Candesartan, Gemfibrozil, and Metoprolol.
What works well with Coenzyme Q10?
Coenzyme Q10 pairs synergistically with Acetyl-L-Carnitine, Alpha-Lipoic Acid, Amlodipine, Atenolol, and Atorvastatin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Coenzyme Q10 with Berberine?
NutriStack classifies the Coenzyme Q10 and Berberine pairing as caution: Berberine may inhibit mitochondrial Complex I, similar to metformin. CoQ10 supplementation may help offset potential mitochondrial effects. Consider adding CoQ10 when taking berberine long-term to support mitochondrial function.
Check your whole stack
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