Supplement·Interactions·Reviewed June 9, 2026
Creatine interactions.
Creatine has 32 documented interactions in the NutriStack database: 11 that need timing or caution and 21 that work synergistically. The full list, with what each pairing does, is below.
Creatine at a glance.
A quick, data-grounded summary. The full table is below.
Creatine has 32 documented interactions in the NutriStack database: 11 that need timing or caution and 21 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with creatine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Elamipretide (SS-31) | Caution | Creatine may affect muscle performance metrics and complicate interpretation of treatment response. |
| Famciclovir | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Famciclovir, which depends on kidney function for dosing or... |
| GHRP-2 | Caution | Creatine water weight can obscure edema or rapid weight changes from GH secretagogue use. |
| GHRP-6 | Caution | Creatine-related water weight can mask edema or rapid weight gain from GH secretagogue effects. |
| Hexarelin | Caution | Creatine-related water weight can mask edema from GH-axis stimulation. |
| MK-677 (Ibutamoren) | Caution | Both can increase scale weight or water retention signals; MK-677 edema can be clinically important. |
| MOTS-c | Caution | Creatine may improve training output and confound interpretation of MOTS-c exercise claims. |
| Tenofovir Disoproxil | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing... |
| Tesamorelin | Caution | Creatine can increase body water and scale weight, while tesamorelin can cause edema or fluid-related symptoms. |
| Valganciclovir | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Valganciclovir, which depends on kidney function for dosing or... |
| Vancomycin | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Vancomycin, which depends on kidney function for dosing or toxicity... |
| Alpha-GPC | Synergy | Both enhance physical and cognitive performance. Creatine buffers ATP in muscles and brain; Alpha-GPC supports cholinergic signaling and growth... |
| Alpha-Lipoic Acid | Synergy | Alpha-lipoic acid increases skeletal muscle uptake and storage of creatine, raising total creatine and phosphocreatine content above what creatine... |
| BCAAs | Synergy | Both support resistance training adaptations through different pathways; combined use is common in performance protocols. |
| Beta-Alanine | Synergy | Creatine enhances ATP regeneration while beta-alanine buffers intracellular acid (via carnosine) during high-intensity exercise. The combination... details → |
| Carnosine | Synergy | Both can support high-intensity exercise capacity by different mechanisms, so athletes sometimes combine carnosine (or its precursor beta-alanine)... |
| Citrulline Malate | Synergy | Creatine and citrulline target different performance mechanisms. |
| Cordyceps | Synergy | Both enhance ATP availability through complementary mechanisms. Cordyceps supports mitochondrial ATP production; creatine buffers ATP via... |
| Ecdysterone | Synergy | Creatine has stronger evidence and may complement any experimental anabolic signaling from ecdysterone. |
| Essential Amino Acids | Synergy | EAAs and creatine support different components of lean mass and training adaptation. |
| Glycerol | Synergy | Both increase body water through different mechanisms and may enhance training fullness. |
| HMB | Synergy | Complementary effects on lean mass and strength, with creatine enhancing high-intensity performance and HMB reducing muscle protein breakdown. |
| Magnesium Citrate | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Magnesium Glycinate | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Magnesium L-Threonate | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Magnesium Malate | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Magnesium Taurate | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Sodium Bicarbonate | Synergy | Creatine and bicarbonate may support different limits to high-intensity performance. |
| Taurine | Synergy | Taurine and creatine are both cell-volumizing osmolytes that support muscle hydration and performance, and are frequently combined in pre-workout... |
| Trimethylglycine | Synergy | Endogenous creatine synthesis consumes a large share of the body's SAMe-derived methyl groups. Supplementing creatine reduces methylation demand,... |
| Vitamin D3 | Synergy | Both support musculoskeletal function. Vitamin D3 enhances muscle protein synthesis, and creatine increases phosphocreatine stores for energy. |
| Whey Protein | Synergy | Whey and creatine are complementary for strength and lean mass goals. |
The full creatine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common creatine questions.
Quick answers drawn from the table above.
What interacts with Creatine?
In the NutriStack database, Creatine has 32 documented interactions with other supplements and medications. The most notable include Elamipretide (SS-31), Famciclovir, GHRP-2, GHRP-6, and Hexarelin.
What works well with Creatine?
Creatine pairs synergistically with Alpha-GPC, Alpha-Lipoic Acid, BCAAs, Beta-Alanine, and Carnosine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Creatine with Elamipretide (SS-31)?
NutriStack classifies the Creatine and Elamipretide (SS-31) pairing as caution: Creatine may affect muscle performance metrics and complicate interpretation of treatment response. Keep supplement use stable during monitored strength testing.
Check your whole stack
See how creatine fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.