Supplement·Interactions·Reviewed June 9, 2026
Ergothioneine interactions.
Ergothioneine has 4 documented interactions in the NutriStack database: 4 that work synergistically. The full list, with what each pairing does, is below.
Ergothioneine at a glance.
A quick, data-grounded summary. The full table is below.
Ergothioneine has 4 documented interactions in the NutriStack database: 4 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with ergothioneine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Coenzyme Q10 | Synergy | Both target mitochondrial function and oxidative stress through distinct routes, so co-supplementation may offer complementary mitochondrial... |
| Green Tea Extract | Synergy | Green tea catechins and ergothioneine are both dietary antioxidants with anti-inflammatory activity that can act through complementary mechanisms. |
| NAC | Synergy | Both compounds support cellular thiol-based antioxidant defenses. Ergothioneine is a stable, transporter-accumulated antioxidant, while... |
| Vitamin C | Synergy | Vitamin C is an aqueous-phase antioxidant and can help regenerate other antioxidants, while ergothioneine provides stable intracellular and... |
The full ergothioneine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common ergothioneine questions.
Quick answers drawn from the table above.
What interacts with Ergothioneine?
In the NutriStack database, Ergothioneine has 4 documented interactions with other supplements and medications. The most notable include Coenzyme Q10, Green Tea Extract, NAC, and Vitamin C.
What works well with Ergothioneine?
Ergothioneine pairs synergistically with Coenzyme Q10, Green Tea Extract, NAC, and Vitamin C in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Ergothioneine with Coenzyme Q10?
NutriStack classifies the Ergothioneine and Coenzyme Q10 pairing as synergy: Both target mitochondrial function and oxidative stress through distinct routes, so co-supplementation may offer complementary mitochondrial antioxidant support. Combining is reasonable for mitochondrial support; take CoQ10 with a fat-containing meal for absorption. No timing conflict with ergothioneine.
Check your whole stack
See how ergothioneine fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.