Supplement·Interactions·Reviewed June 9, 2026
Evening Primrose Oil interactions.
Evening Primrose Oil has 17 documented interactions in the NutriStack database: 1 that need timing or caution and 16 that work synergistically. The full list, with what each pairing does, is below.
Evening Primrose Oil at a glance.
A quick, data-grounded summary. The full table is below.
Evening Primrose Oil has 17 documented interactions in the NutriStack database: 1 that need timing or caution and 16 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with evening primrose oil.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Warfarin | Caution | Evening primrose oil is rich in gamma-linolenic acid (GLA), which has documented antiplatelet activity and can prolong bleeding time. Adverse-event... |
| Astaxanthin | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Astaxanthin. |
| Coenzyme Q10 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Coenzyme Q10. |
| Coenzyme Q10 Ubiquinol | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Coenzyme Q10 Ubiquinol. |
| Curcumin Phytosome | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Curcumin Phytosome. |
| Lutein | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Lutein. |
| Lycopene | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Lycopene. |
| Resveratrol | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol. |
| Turmeric/Curcumin | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Turmeric/Curcumin. |
| Vitamin A | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin A. |
| Vitamin D2 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin D2. |
| Vitamin D3 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin D3. |
| Vitamin E | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin E. |
| Vitamin K1 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin K1. |
| Vitamin K2 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin K2. |
| Vitamin K2 MK-4 | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin K2 MK-4. |
| Zeaxanthin | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Zeaxanthin. |
The full evening primrose oil profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common evening primrose oil questions.
Quick answers drawn from the table above.
What interacts with Evening Primrose Oil?
In the NutriStack database, Evening Primrose Oil has 17 documented interactions with other supplements and medications. The most notable include Warfarin, Astaxanthin, Coenzyme Q10, Coenzyme Q10 Ubiquinol, and Curcumin Phytosome.
What works well with Evening Primrose Oil?
Evening Primrose Oil pairs synergistically with Astaxanthin, Coenzyme Q10, Coenzyme Q10 Ubiquinol, Curcumin Phytosome, and Lutein in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Evening Primrose Oil with Warfarin?
NutriStack classifies the Evening Primrose Oil and Warfarin pairing as caution: Evening primrose oil is rich in gamma-linolenic acid (GLA), which has documented antiplatelet activity and can prolong bleeding time. Adverse-event reviews of warfarin... Avoid evening primrose oil while on warfarin. If you take it for menstrual symptoms or skin conditions, tell your anticoagulation clinic, keep the...
Check your whole stack
See how evening primrose oil fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.