Supplement·Interactions·Reviewed June 9, 2026
Fish Oil interactions.
Fish Oil has 88 documented interactions in the NutriStack database: 46 that need timing or caution and 42 that work synergistically. The full list, with what each pairing does, is below.
In short
Fish Oil at a glance.
A quick, data-grounded summary. The full table is below.
Fish Oil has 88 documented interactions in the NutriStack database: 46 that need timing or caution and 42 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with fish oil.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| American Ginseng | Caution | Ginseng can inhibit platelet aggregation, and high-dose fish oil also has mild antiplatelet activity, so combining them may modestly increase... |
| Anthocyanins (Bilberry Extract) | Caution | Both bilberry anthocyanins and high-dose fish oil can mildly reduce platelet aggregation. Taken together, and especially alongside anticoagulant or... |
| Apixaban | Caution | Fish oil has antiplatelet and antithrombotic properties that may increase bleeding risk when combined with apixaban. While moderate doses are likely... details → |
| Aspirin Low-Dose | Caution | Fish oil has antiplatelet properties that add to aspirin's cyclooxygenase inhibition, potentially increasing bleeding risk. While the combination is... details → |
| Black Seed Oil | Caution | Both can modestly lower blood pressure and affect platelet function, so combining them may produce additive reductions in blood pressure and a small... |
| Bromelain | Caution | Both have mild antiplatelet activity; combined chronic use can additively raise bleeding tendency. |
| Cat's Claw | Caution | Both agents have mild antiplatelet activity, so combining them may modestly increase bleeding tendency, especially with anticoagulant or... |
| Celecoxib | Caution | Fish oil has mild antiplatelet effects and may add bleeding risk to celecoxib in higher-risk situations. Modern randomized-trial evidence suggests... details → |
| Cerebrolysin | Caution | Fish oil may modestly increase bruising risk around injections or acute neurologic events. |
| Clopidogrel | Caution | Fish oil has antiplatelet properties that may add to clopidogrel's platelet inhibition, increasing the overall bleeding risk. While moderate fish... details → |
| Curcumin Phytosome | Caution | Both have blood-thinning properties. High doses of both together may increase bleeding risk. details → |
| Dabigatran | Caution | Fish oil's omega-3 fatty acids reduce platelet thromboxane A2 and can prolong bleeding time. Added to dabigatran's direct thrombin inhibition,... |
| Diclofenac | Caution | High-dose fish oil may add mild antiplatelet effects to diclofenac's GI bleeding risk. Standard omega-3 doses usually do not cause major bleeding in... details → |
| Dong Quai | Caution | High-dose fish oil may add to bleeding tendency with dong quai. |
| Enoxaparin | Caution | Fish oil's omega-3 fatty acids reduce platelet thromboxane A2 and prolong bleeding time. Added to enoxaparin's anti-factor Xa activity, high-dose... |
| Epicatechin | Caution | Both may have mild antiplatelet or vascular effects at high doses. |
| Escitalopram | Caution | Escitalopram impairs platelet aggregation by depleting platelet serotonin stores, and high-dose fish oil adds modest antiplatelet activity by... details → |
| Fluoxetine | Caution | Fluoxetine depletes platelet serotonin and impairs aggregation, while high-dose fish oil adds modest antiplatelet activity. Observational data show... details → |
| Gemfibrozil | Caution | High-dose omega-3 fatty acids (EPA/DHA) and gemfibrozil are both used to lower triglycerides and are sometimes co-prescribed. Each can modestly... |
| Ginger Extract | Caution | Both reduce platelet aggregation, so the combination can additively increase bleeding tendency, especially with concurrent anticoagulants. |
| Ginkgo Biloba | Caution | Both have mild antiplatelet activity; combined chronic use can additively increase bleeding tendency, especially with concurrent NSAIDs or... |
| Holy Basil/Tulsi | Caution | Holy basil has mild antiplatelet activity; combined with fish oil's effect on thromboxane, bleeding risk is theoretically additive. |
| Ibuprofen | Caution | Both ibuprofen and fish oil have antiplatelet effects. Combined use may modestly increase GI bleeding risk. However, the interaction is generally... details → |
| Icosapent Ethyl | Caution | Fish Oil may increase bleeding tendency and can be a concern with Icosapent Ethyl when additional omega-3 products increase total antiplatelet... |
| LL-37 | Caution | Fish oil may increase bruising around wounds or procedures where topical or injectable peptide use is being considered. |
| Meloxicam | Caution | High-dose fish oil may add mild antiplatelet activity to meloxicam's GI bleeding risk. Most randomized-trial data do not show major bleeding... details → |
| Naproxen | Caution | Naproxen has stronger antiplatelet effects than most NSAIDs. Combined with fish oil's antiplatelet properties, there is additive bleeding risk. details → |
| Panax Ginseng | Caution | Panax ginseng has antiplatelet activity, and combining it with high-dose fish oil, which also reduces platelet aggregation, may additively increase... |
| Paroxetine | Caution | Paroxetine depletes platelet serotonin stores and impairs aggregation; high-dose fish oil adds antiplatelet activity. Together they raise bleeding... details → |
| Pentadeca Arginate (PDA) | Caution | Fish oil can add bruising risk around injections or procedures. |
| Prasugrel | Caution | Fish oil's omega-3 fatty acids reduce platelet thromboxane A2 generation and modestly prolong bleeding time. Added to prasugrel's potent... |
| Rivaroxaban | Caution | Fish oil has antiplatelet and antithrombotic properties that may increase bleeding risk when combined with rivaroxaban. The combination creates... details → |
| Rutin | Caution | Both rutin (and its quercetin metabolite) and the omega-3 fatty acids in fish oil can modestly reduce platelet aggregation. Used together, and... |
| Sea Buckthorn Oil | Caution | Combining multiple fatty acid oils can increase GI side effects and may modestly increase bleeding tendency in susceptible users. |
| Serrapeptase | Caution | Fish oil has mild antiplatelet activity that can add to serrapeptase's fibrinolytic effect, modestly increasing the chance of bruising or prolonged... |
| Sertraline | Caution | Sertraline depletes platelet serotonin stores and impairs platelet aggregation, raising bleeding risk by roughly 40-55% across observational... details → |
| Thymosin Beta-4 | Caution | Fish oil may modestly increase bleeding or bruising tendency, which matters around wounds, procedures, or injections. |
| Ticagrelor | Caution | Fish oil's omega-3 fatty acids reduce platelet thromboxane A2 generation and modestly prolong bleeding time. Added to ticagrelor's P2Y12 inhibition,... |
| Tocotrienols | Caution | High-dose fish oil plus vitamin E family supplements may add bleeding tendency. |
| Trimethylglycine | Caution | High-dose betaine can modestly raise LDL cholesterol and triglycerides in some people. Pairing with omega-3 fish oil, which tends to lower... |
| Turmeric/Curcumin | Caution | Both have blood-thinning properties. High doses of both together may increase bleeding risk. details → |
| Vinpocetine | Caution | High-dose fish oil may modestly increase bleeding tendency and can compound vinpocetine caution. |
| Vitamin E | Caution | High-dose fish oil increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores. details → |
| Vortioxetine | Caution | Vortioxetine may increase bleeding tendency through serotonin effects on platelets. High-dose fish oil can have mild antiplatelet effects. |
| Warfarin | Caution | Fish oil may potentiate warfarin's anticoagulant effect through its own antiplatelet and antithrombotic properties. While moderate doses (1-2g/day)... details → |
| Fisetin | Timing Sensitive | Fisetin is fat-soluble and poorly absorbed; taking it alongside an omega-3 fish oil softgel provides a convenient dietary-fat carrier to support... |
| Acitretin | Synergy | Acitretin can raise triglycerides, and fish oil may help reduce retinoid-associated hypertriglyceridemia. Direct evidence is strongest for... |
| Amlodipine | Synergy | Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (about 2-3 mmHg systolic at doses of 2-3 g/day) and lower... details → |
| Astaxanthin | Synergy | Astaxanthin is fat-soluble and absorbs best with dietary fat. It also protects omega-3 fatty acids from oxidation. details → |
| Atenolol | Synergy | Fish oil (EPA/DHA) at 2-3 g/day produces small reductions in blood pressure and lowers triglycerides, complementing atenolol's hemodynamic effects... details → |
| Atorvastatin | Synergy | Fish oil omega-3 fatty acids can add triglyceride lowering to statin therapy. Randomized studies of high-dose omega-3 fatty acids added to... details → |
| Bempedoic Acid | Synergy | Bempedoic acid lowers LDL cholesterol via inhibition of ATP-citrate lyase, while prescription-grade omega-3 fatty acids (especially icosapent ethyl)... |
| Carvedilol | Synergy | Omega-3 fatty acids modestly reduce blood pressure and lower triglycerides, and have separate benefits in heart failure (reducing all-cause... details → |
| CLA | Synergy | Combining CLA with fish oil may offset CLA's tendency to worsen some lipid and inflammatory markers, since omega-3s improve triglycerides and have... |
| Coenzyme Q10 | Synergy | CoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle. details → |
| Coenzyme Q10 Ubiquinol | Synergy | CoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle. details → |
| Evolocumab | Synergy | Fish Oil may add modest lipid-lowering effects to Evolocumab for triglyceride management. |
| Ezetimibe | Synergy | Fish oil (EPA and DHA) primarily lowers triglycerides and modestly affects other lipid fractions through mechanisms distinct from ezetimibe's... |
| Fenofibrate | Synergy | Fish Oil may add modest lipid-lowering effects to Fenofibrate for triglyceride lowering. |
| Fucoxanthin | Synergy | Fucoxanthin is highly lipophilic and is absorbed better when taken with dietary fat. Co-administration with fish oil (or other oils) increases its... |
| Garlic Extract | Synergy | Both lower LDL, blood pressure, and have mild antiplatelet effects; combined use is broadly cardio-supportive. |
| Hawthorn (Crataegus) | Synergy | Fish oil may complement cardiovascular risk support, though direct hawthorn-fish oil trials are lacking. |
| Hesperidin | Synergy | Hesperidin and omega-3 fish oil act through complementary mechanisms to improve endothelial function and reduce vascular inflammation. |
| Isotretinoin | Synergy | Fish oil may help blunt isotretinoin-related triglyceride increases, especially if triglycerides are already elevated before treatment. Human data... details → |
| Lion's Mane | Synergy | The pair supports brain health through complementary pathways, with Lion's Mane promoting neurotrophic factor production and Fish Oil supplying DHA... |
| Lisinopril | Synergy | Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE... details → |
| Lithium | Synergy | Fish oil (EPA/DHA) may have additive mood-stabilizing benefits when combined with lithium. Omega-3 fatty acids have demonstrated modest efficacy in... details → |
| Losartan | Synergy | Fish Oil reduces blood pressure modestly and has independent renoprotective effects through reduced angiotensin II generation and downregulation of... details → |
| Lutein | Synergy | Fish oil provides dietary fat that improves absorption of fat-soluble lutein, and its omega-3 fatty acids complement lutein in supporting retinal... |
| Methotrexate | Synergy | Fish oil (EPA/DHA) may have additive anti-inflammatory effects when combined with methotrexate for rheumatic conditions. Some studies suggest that... details → |
| Metoprolol | Synergy | Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (~2-3 mmHg systolic at doses of 2-3 g/day) and lower... details → |
| MitoQ (Mitoquinone) | Synergy | MitoQ concentrates in mitochondrial membranes that are rich in polyunsaturated phospholipids and limits lipid peroxidation, while omega-3 fatty... |
| Niacin (Prescription) | Synergy | Prescription niacin and fish oil (omega-3 fatty acids EPA/DHA) both lower triglycerides through complementary mechanisms and are sometimes used... |
| Omega-7 | Synergy | Omega-7 (palmitoleic acid) and fish oil omega-3s have complementary lipid-modulating effects, with some evidence that combined intake supports... |
| Ox Bile | Synergy | Ox bile emulsifies the fat in fish oil, improving digestion and absorption of omega-3 fatty acids, which can be useful for people with reduced bile... |
| Phosphatidylserine | Synergy | Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes. |
| Pomegranate Extract | Synergy | Both support cardiometabolic and vascular health, but high doses may add bleeding tendency. |
| Quercetin | Synergy | Quercetin and fish oil reduce inflammation through different pathways, giving an additive anti-inflammatory effect. |
| Ramipril | Synergy | Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE... details → |
| Resveratrol | Synergy | Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties. |
| Risperidone | Synergy | Fish oil, as a source of omega-3 polyunsaturated fatty acids, has been studied as an adjunct in recent-onset psychosis patients treated with... details → |
| Rosuvastatin | Synergy | Fish oil omega-3 fatty acids can be used with rosuvastatin for residual hypertriglyceridemia. Human pharmacokinetic studies found no clinically... details → |
| Saw Palmetto | Synergy | Both support prostate health through complementary mechanisms; combined use is common in men's BPH protocols. |
| Simvastatin | Synergy | Fish oil omega-3 fatty acids can improve triglyceride and non-HDL cholesterol measures when added to simvastatin in patients with residual... details → |
| Tangeretin | Synergy | Tangeretin and omega-3 fish oil work through complementary mechanisms to improve lipid profiles and reduce vascular inflammation. |
| Vitamin D3 | Synergy | Vitamin D3 is fat-soluble and absorption improves when taken with omega-3 fatty acids. Both support cardiovascular and immune health. details → |
| Vitamin K2 | Synergy | K2 (MK-7) is fat-soluble and absorption increases with dietary fat. Fish oil provides an excellent fat vehicle. details → |
| Vitamin K2 MK-4 | Synergy | K2 (MK-7) is fat-soluble and absorption increases with dietary fat. Fish oil provides an excellent fat vehicle. details → |
Go deeper
The full fish oil profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common fish oil questions.
Quick answers drawn from the table above.
What interacts with Fish Oil?
In the NutriStack database, Fish Oil has 88 documented interactions with other supplements and medications. The most notable include American Ginseng, Anthocyanins (Bilberry Extract), Apixaban, Aspirin Low-Dose, and Black Seed Oil.
What works well with Fish Oil?
Fish Oil pairs synergistically with Acitretin, Amlodipine, Astaxanthin, Atenolol, and Atorvastatin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Fish Oil with American Ginseng?
NutriStack classifies the Fish Oil and American Ginseng pairing as caution: Ginseng can inhibit platelet aggregation, and high-dose fish oil also has mild antiplatelet activity, so combining them may modestly increase bleeding tendency,... Generally low risk at typical doses, but use caution if also taking anticoagulants or antiplatelet medication, and discontinue both before surgery...
Check your whole stack
See how fish oil fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.