Supplement·Interactions·Reviewed June 9, 2026
Garlic Extract interactions.
Garlic Extract has 56 documented interactions in the NutriStack database: 47 that need timing or caution and 9 that work synergistically. The full list, with what each pairing does, is below.
In short
Garlic Extract at a glance.
A quick, data-grounded summary. The full table is below.
Garlic Extract has 56 documented interactions in the NutriStack database: 47 that need timing or caution and 9 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with garlic extract.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Amlodipine | Caution | Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients in meta-analysis. Added on top of... details → |
| Andrographis | Caution | Both may have antiplatelet or bleeding-related cautions, especially around surgery or anticoagulants. |
| Apixaban | Caution | Concentrated garlic extracts inhibit platelet aggregation via allicin and related organosulfur compounds and have been linked to surgical bleeding.... |
| Aspirin Low-Dose | Caution | Garlic supplements inhibit platelet aggregation and have been compared head-to-head with aspirin and clopidogrel in clinical studies showing... details → |
| Atenolol | Caution | Aged garlic extract reduces systolic blood pressure by approximately 8 mmHg in hypertensives. Layered on atenolol, the combined effect can drive... details → |
| Beetroot Extract (Dietary Nitrate) | Caution | Both may lower blood pressure and have vascular effects. |
| Black Seed Oil | Caution | Two supplements with reproducible antihypertensive effects in human trials. Combined, the blood-pressure reduction can be additive, which is helpful... details → |
| Candesartan | Caution | Garlic extract can produce a modest blood-pressure-lowering effect. Taken with candesartan, the antihypertensive effects may be additive, which... |
| Captopril | Caution | Garlic extract has modest blood-pressure-lowering properties and may add to the antihypertensive effect of captopril. While this can be beneficial,... |
| Citrulline Malate | Caution | Both may lower blood pressure through vascular mechanisms. |
| Clopidogrel | Caution | Garlic supplements inhibit platelet aggregation and have been studied head-to-head with clopidogrel. Combined with clopidogrel's irreversible P2Y12... |
| Dabigatran | Caution | Concentrated garlic supplements inhibit platelet aggregation. Added to dabigatran's direct thrombin inhibition, the antiplatelet effect can raise... |
| Diclofenac | Caution | Concentrated garlic extract may increase bleeding tendency when combined with diclofenac. Diclofenac can injure the GI lining, while garlic... |
| Diltiazem | Caution | Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients. Combined with diltiazem's... details → |
| Dong Quai | Caution | Garlic extract may add to dong quai bleeding risk. |
| Enoxaparin | Caution | Concentrated garlic supplements inhibit platelet aggregation through allicin and related compounds and have been linked to perioperative bleeding.... |
| Felodipine | Caution | Garlic supplements have modest blood-pressure-lowering activity and can add to the antihypertensive effect of felodipine. The combined effect is... |
| Fenofibrate | Caution | Fenofibrate has antiplatelet-like effects and is reported to potentiate the action of anticoagulants. Concentrated garlic extract has mild... |
| Fenugreek | Caution | Fenugreek has documented, though mostly preclinical, antiplatelet effects, and garlic extract is a well-established platelet aggregation inhibitor... |
| Ginger Extract | Caution | Combined antiplatelet activity may modestly increase bleeding tendency, particularly in those on anticoagulant or antiplatelet drugs or approaching... |
| Ginkgo Biloba | Caution | Both are common in geriatric and cardiovascular use; combined antiplatelet effects are additive. |
| Hawthorn (Crataegus) | Caution | Both may lower blood pressure and affect platelet activity. |
| Ibuprofen | Caution | Concentrated garlic extract may add antiplatelet activity to ibuprofen's bleeding risk. This is most relevant with high-dose garlic products,... |
| Icosapent Ethyl | Caution | Garlic Extract may increase bleeding tendency and can be a concern with Icosapent Ethyl when garlic is combined with omega-3 therapy or... |
| Losartan/Hydrochlorothiazide | Caution | Garlic extract has a modest blood-pressure-lowering effect in hypertensive patients. When added to an effective antihypertensive combination such as... |
| Metoprolol | Caution | Aged garlic extract lowers systolic blood pressure by roughly 8 mmHg in hypertensive patients, comparable to first-line antihypertensives. Added to... details → |
| Naproxen | Caution | Concentrated garlic extract may add antiplatelet effects to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper GI... |
| Nattokinase | Caution | Garlic has antiplatelet activity and nattokinase has fibrinolytic activity, so combining them can additively impair clotting and raise bleeding... |
| Nebivolol | Caution | Garlic extract has a modest antihypertensive effect, particularly aged garlic extract, and may add to the blood-pressure-lowering action of... |
| Nifedipine | Caution | Aged garlic extract lowers systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients. Stacked on top of nifedipine's... details → |
| Olive Leaf Extract | Caution | Olive leaf extract and garlic extract both modestly lower blood pressure, so combined use may produce additive hypotensive effects. details → |
| Pentadeca Arginate (PDA) | Caution | Garlic may increase bleeding tendency, which matters around injury, procedures, or injections. |
| Perindopril | Caution | Garlic extract has modest blood-pressure-lowering properties demonstrated in meta-analyses. Combined with perindopril, the antihypertensive effects... |
| Pomegranate Extract | Caution | Both may lower blood pressure and have antiplatelet effects. |
| Prasugrel | Caution | Concentrated garlic supplements inhibit platelet aggregation. Combined with prasugrel's potent irreversible P2Y12 inhibition, garlic supplements... |
| Propranolol | Caution | Garlic extract lowers blood pressure on its own and, in animal studies, has been shown to potentiate the antihypertensive and cardioprotective... details → |
| Pygeum Africanum | Caution | Pygeum is usually well tolerated, but combining multiple supplements before urologic procedures can complicate bleeding and medication review. |
| Rivaroxaban | Caution | Concentrated garlic extracts inhibit platelet aggregation and have been linked to perioperative bleeding. Added to rivaroxaban's factor Xa... |
| Royal Jelly | Caution | Royal Jelly and Garlic Extract both lower blood pressure through nitric-oxide-driven vasodilation (Royal Jelly additionally via ACE-inhibitory... |
| Sertraline | Caution | Sertraline depletes platelet serotonin and impairs aggregation; concentrated garlic extracts (allicin, ajoene) inhibit platelet aggregation by... |
| Telmisartan | Caution | Garlic extract has modest blood-pressure-lowering and vasodilatory effects. When combined with telmisartan, the antihypertensive effects can be... |
| Ticagrelor | Caution | Concentrated garlic supplements inhibit platelet aggregation. Combined with ticagrelor's P2Y12 inhibition, garlic supplements stack antiplatelet... |
| Valganciclovir | Caution | Garlic Extract may increase bleeding tendency and can be a concern with Valganciclovir when valganciclovir causes thrombocytopenia or the patient is... |
| Vinpocetine | Caution | Garlic extract can have antiplatelet effects that may add to vinpocetine-related bleeding concerns. |
| Warfarin | Caution | Garlic supplements possess antiplatelet properties that may increase bleeding risk when combined with warfarin. Several case reports have documented... details → |
| Bifidobacterium infantis 35624 | Timing Sensitive | High-dose garlic extract has antimicrobial properties and may worsen gas when combined with probiotics in sensitive users. |
| Lactobacillus acidophilus NCFM | Timing Sensitive | High-dose garlic extract can have antimicrobial and GI effects that may interfere with probiotic tolerance. |
| Bempedoic Acid | Synergy | Aged garlic extract produces modest reductions in LDL and total cholesterol and is sometimes used by patients pursuing additional lipid lowering.... |
| Berberine | Synergy | Garlic and berberine both lower LDL cholesterol and triglycerides through different mechanisms, giving additive lipid-lowering when combined. details → |
| Coenzyme Q10 | Synergy | Aged garlic extract combined with coenzyme Q10 improved endothelial function and vascular elasticity in a randomized trial, with both agents... details → |
| Enalapril | Synergy | Garlic Extract lowers blood pressure modestly and has independent ACE-inhibitory activity in vitro. When combined with enalapril the effects are... details → |
| Fish Oil | Synergy | Both lower LDL, blood pressure, and have mild antiplatelet effects; combined use is broadly cardio-supportive. |
| Lisinopril | Synergy | Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives) and has independent ACE-inhibitory activity in... details → |
| Losartan | Synergy | Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives). When combined with the ARB losartan, the effects... details → |
| Ramipril | Synergy | Garlic Extract lowers blood pressure modestly and has independent ACE-inhibitory activity in vitro. When combined with ramipril the effects are... details → |
| Valsartan | Synergy | Garlic Extract lowers blood pressure modestly. When combined with the ARB valsartan, the effects are additive, which can help patients with... details → |
Go deeper
The full garlic extract profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common garlic extract questions.
Quick answers drawn from the table above.
What interacts with Garlic Extract?
In the NutriStack database, Garlic Extract has 56 documented interactions with other supplements and medications. The most notable include Amlodipine, Andrographis, Apixaban, Aspirin Low-Dose, and Atenolol.
What works well with Garlic Extract?
Garlic Extract pairs synergistically with Bempedoic Acid, Berberine, Coenzyme Q10, Enalapril, and Fish Oil in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Garlic Extract with Amlodipine?
NutriStack classifies the Garlic Extract and Amlodipine pairing as caution: Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients in meta-analysis. Added on top of amlodipine, the... If you take amlodipine, monitor your blood pressure for 2-4 weeks after starting garlic extract. If readings drop below your usual range or you...
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