Supplement·Interactions·Reviewed June 9, 2026
Ginkgo Biloba interactions.
Ginkgo Biloba has 67 documented interactions in the NutriStack database: 3 to avoid or watch closely, 62 that need timing or caution, and 2 that work synergistically. The full list, with what each pairing does, is below.
In short
Ginkgo Biloba at a glance.
A quick, data-grounded summary. The full table is below.
Ginkgo Biloba has 67 documented interactions in the NutriStack database: 3 to avoid or watch closely, 62 that need timing or caution, and 2 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with ginkgo biloba.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Carbamazepine | Conflict | Ginkgo biloba has case reports of precipitating seizures in people with previously controlled epilepsy. That directly conflicts with carbamazepine's... |
| Phenobarbital | Conflict | Ginkgo has seizure case reports and may undermine seizure control. |
| Primidone | Conflict | Ginkgo may lower seizure threshold and is undesirable with anticonvulsant therapy. |
| Apixaban | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Case reports document spontaneous bleeding (intracranial, ocular,... details → |
| Aspirin Low-Dose | Caution | Ginkgo biloba's potent antiplatelet activity (PAF antagonism) combined with aspirin's COX-1 inhibition creates significant additive bleeding risk.... details → |
| Atorvastatin | Caution | A human study found that high-dose Ginkgo biloba extract modestly lowered atorvastatin exposure, including a larger drop in peak concentration.... |
| Azathioprine | Caution | Ginkgo may increase bleeding tendency and could compound bleeding risk if azathioprine causes thrombocytopenia. |
| Bromelain | Caution | Bromelain has mild antiplatelet and fibrinolytic activity that can add to ginkgo's platelet-inhibiting effect, modestly increasing bleeding risk. |
| Celecoxib | Caution | Ginkgo biloba may add bleeding risk to celecoxib, particularly in people who also take aspirin or have ulcer history. Celecoxib is more GI-sparing... |
| Cerebrolysin | Caution | Ginkgo is used for cognition and may increase bleeding risk, complicating neurologic and procedural care. |
| Chamomile | Caution | Chamomile has coumarin-like constituents and ginkgo can increase bleeding tendency. |
| Citalopram | Caution | Citalopram impairs platelet aggregation by depleting platelet serotonin; Ginkgo's ginkgolides inhibit platelet-activating factor. The combination... details → |
| Clomipramine | Caution | Ginkgo has case reports of seizures and may increase bleeding tendency. Clomipramine can lower seizure threshold and may increase bleeding risk... |
| Clopidogrel | Caution | Ginkgo biloba has significant antiplatelet activity (PAF antagonism) that adds to clopidogrel's platelet inhibition, substantially increasing... details → |
| Clozapine | Caution | Ginkgo has seizure case reports, and clozapine has a dose-related seizure boxed warning. |
| Dabigatran | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to dabigatran's direct thrombin inhibition, the antiplatelet... details → |
| Diclofenac | Caution | Ginkgo biloba may increase bleeding risk with diclofenac. Ginkgo has reported spontaneous bleeding cases, and diclofenac can cause NSAID-related GI... |
| Donepezil | Caution | Both donepezil and ginkgo biloba have cholinergic and cognitive effects. Some studies have explored the combination, but additive cholinergic side... details → |
| Dong Quai | Caution | Both may increase bleeding tendency. |
| Enoxaparin | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation, and case reports link it to spontaneous bleeding. Combined with... details → |
| Escitalopram | Caution | Escitalopram impairs platelet aggregation by depleting platelet serotonin; Ginkgo's ginkgolides inhibit platelet-activating factor. Combined... details → |
| Fish Oil | Caution | Both have mild antiplatelet activity; combined chronic use can additively increase bleeding tendency, especially with concurrent NSAIDs or... |
| Fluoxetine | Caution | Fluoxetine depletes platelet serotonin and impairs aggregation; ginkgo's ginkgolides inhibit platelet-activating factor. The combination compounds... details → |
| Fluvoxamine | Caution | Fluvoxamine impairs platelet aggregation by depleting platelet serotonin; Ginkgo's ginkgolides inhibit platelet-activating factor. Combined... details → |
| Galantamine | Caution | Ginkgo is sometimes used for cognition but may increase bleeding risk and has seizure case reports. Galantamine is used in a population vulnerable... |
| Garlic Extract | Caution | Both are common in geriatric and cardiovascular use; combined antiplatelet effects are additive. |
| Ginger Extract | Caution | Both have mild antiplatelet activity; clinical bleeding events from this combination alone are rare but theoretical. |
| Grape Seed Extract | Caution | Used together, grape seed extract and ginkgo may additively reduce platelet aggregation and impair clotting. For healthy people at usual supplement... |
| Haloperidol | Caution | Ginkgo has seizure case reports, and haloperidol can lower seizure threshold in susceptible patients. |
| Holy Basil/Tulsi | Caution | Holy basil and ginkgo biloba both reduce platelet aggregation, so taking them together can additively impair clotting and theoretically raise... |
| Huperzine A | Caution | Both are commonly used for cognition and can increase headache, dizziness, insomnia, or GI side effects when stacked. |
| Ibuprofen | Caution | Ginkgo biloba may add antiplatelet effects to ibuprofen and has a published case of fatal intracerebral bleeding with ibuprofen. Ibuprofen also... details → |
| Icosapent Ethyl | Caution | Ginkgo Biloba may increase bleeding tendency and can be a concern with Icosapent Ethyl when ginkgo is combined with omega-3 therapy or... |
| Lacosamide | Caution | Ginkgo has seizure case reports and may undermine antiseizure therapy. |
| Levetiracetam Extended-Release | Caution | Ginkgo has seizure case reports and may counter seizure control. |
| Levomilnacipran | Caution | Levomilnacipran may increase bleeding risk, and ginkgo may add mild antiplatelet effects. |
| LL-37 | Caution | Ginkgo may increase bleeding risk and complicate wound assessment. |
| Meloxicam | Caution | Ginkgo biloba may add bleeding risk to meloxicam. Meloxicam can still cause NSAID GI injury despite partial COX-2 selectivity, and ginkgo has case... |
| Naproxen | Caution | Ginkgo biloba may increase bleeding risk when combined with naproxen. Ginkgo has case reports of spontaneous bleeding, while naproxen is a... |
| Nattokinase | Caution | Combining ginkgo with nattokinase increases bleeding risk because both reduce the blood's tendency to clot through different mechanisms. |
| Noopept | Caution | Combining two nootropic products makes headache, dizziness, insomnia, or adverse neurologic effects harder to detect. |
| Oxcarbazepine | Caution | Ginkgo has seizure case reports and is undesirable in patients taking antiseizure medication. |
| Paliperidone | Caution | Ginkgo has seizure case reports, and antipsychotics can lower seizure threshold in susceptible patients. |
| Paroxetine | Caution | Paroxetine depletes platelet serotonin and impairs aggregation; Ginkgo's ginkgolides inhibit platelet-activating factor. The combination compounds... details → |
| Prasugrel | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to prasugrel's potent irreversible P2Y12 inhibition, the... details → |
| Prochlorperazine | Caution | Ginkgo has seizure case reports, and phenothiazines may lower seizure threshold in susceptible patients. |
| Pueraria Mirifica | Caution | Ginkgo can increase bleeding tendency, and estrogenic botanicals can cause abnormal bleeding in susceptible users. |
| Red Clover Isoflavones | Caution | Both may increase bleeding concern, especially at higher doses or before surgery. |
| Rivaroxaban | Caution | Ginkgo biloba is a potent platelet-activating factor (PAF) antagonist and has been linked in case reports to spontaneous intracranial, ocular, and... details → |
| Rivastigmine | Caution | Ginkgo is often used for cognition but may increase bleeding risk and has seizure case reports. Rivastigmine can cause syncope and may be used in... |
| Saffron Extract | Caution | Both may have mild antiplatelet or bleeding-risk considerations. |
| Semax | Caution | Ginkgo may increase bleeding risk and is often used for cognition, complicating neurologic symptom tracking. |
| Serrapeptase | Caution | Ginkgo inhibits platelet-activating factor and serrapeptase is fibrinolytic, so combining them can additively impair hemostasis and increase the... |
| Sertraline | Caution | Sertraline depletes platelet serotonin and impairs aggregation, raising bleeding risk. Ginkgo biloba contains ginkgolides that inhibit... details → |
| Thymosin Beta-4 | Caution | Ginkgo may increase bleeding risk and can complicate wound or procedure recovery. |
| Ticagrelor | Caution | Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to ticagrelor's reversible P2Y12 inhibition, the antiplatelet... details → |
| Valganciclovir | Caution | Ginkgo Biloba may increase bleeding tendency and can be a concern with Valganciclovir when valganciclovir causes thrombocytopenia or the patient is... |
| Vilazodone | Caution | Vilazodone can increase bleeding risk through platelet serotonin effects; ginkgo may also increase bleeding tendency in susceptible patients. |
| Vinpocetine | Caution | Both may affect bleeding risk and both can cause dizziness or headache. |
| Vitamin E | Caution | Both have antiplatelet activity at higher doses; combined use raises bleeding risk in surgical and anticoagulated patients. |
| Vitamin K1 | Caution | Ginkgo's antiplatelet activity can mildly counter vitamin K1's pro-coagulant role; relevant for warfarin patients managing INR through K1 intake. |
| Voriconazole | Caution | Ginkgo biloba has been reported to modestly induce CYP2C19 in some pharmacokinetic studies, and CYP2C19 is a major pathway for voriconazole... |
| Warfarin | Caution | Ginkgo biloba has significant antiplatelet activity that increases bleeding risk when combined with warfarin. Multiple case reports document serious... details → |
| Ziprasidone | Caution | Ginkgo has seizure case reports, and antipsychotics including ziprasidone can lower seizure threshold in susceptible patients. |
| Zonisamide | Caution | Ginkgo has seizure case reports and may undermine antiseizure therapy. |
| Bacopa Monnieri | Synergy | Ginkgo and bacopa support cognition through complementary routes, and combining them may produce additive memory and processing-speed benefits. |
| Maca Root | Synergy | The pair combines Maca's effect on sexual desire with Ginkgo's influence on peripheral blood flow and nitric oxide, offering complementary support... |
Go deeper
The full ginkgo biloba profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common ginkgo biloba questions.
Quick answers drawn from the table above.
What interacts with Ginkgo Biloba?
In the NutriStack database, Ginkgo Biloba has 67 documented interactions with other supplements and medications. The most notable include Carbamazepine, Phenobarbital, Primidone, Apixaban, and Aspirin Low-Dose.
What should you not take with Ginkgo Biloba?
Ginkgo Biloba is flagged against 3 substances in the database, including Carbamazepine, Phenobarbital, and Primidone. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Ginkgo Biloba?
Ginkgo Biloba pairs synergistically with Bacopa Monnieri and Maca Root in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Ginkgo Biloba with Carbamazepine?
NutriStack classifies the Ginkgo Biloba and Carbamazepine pairing as conflict: Ginkgo biloba has case reports of precipitating seizures in people with previously controlled epilepsy. That directly conflicts with carbamazepine's purpose when it is... Avoid ginkgo biloba if you take carbamazepine for epilepsy or have any seizure history. If you already started ginkgo and notice breakthrough...
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