Supplement·Interactions·Reviewed June 9, 2026
Glycine interactions.
Glycine has 6 documented interactions in the NutriStack database: 6 that work synergistically. The full list, with what each pairing does, is below.
Glycine at a glance.
A quick, data-grounded summary. The full table is below.
Glycine has 6 documented interactions in the NutriStack database: 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with glycine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| GABA | Synergy | Combining GABA with glycine layers two distinct inhibitory neurotransmitter systems, which can deepen overall central nervous system calming and... details → |
| L-Methionine | Synergy | Glycine is the acceptor substrate for GNMT, a main enzyme that buffers excess methylation potential created when L-Methionine raises SAMe. Adequate... |
| L-Theanine | Synergy | Both amino acids support sleep through different routes, so combining them may reduce pre-sleep tension and improve sleep quality more than either... |
| Magnesium Glycinate | Synergy | Magnesium glycinate already contains glycine as its chelation partner. Additional glycine further supports sleep and inhibitory neurotransmission. |
| NAC | Synergy | Glycine and NAC (GlyNAC) together provide two of the three amino acids needed for glutathione synthesis. |
| Taurine | Synergy | Glycine and taurine are both inhibitory amino acids that together support relaxation and may aid sleep onset, including glycine's documented... |
The full glycine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common glycine questions.
Quick answers drawn from the table above.
What interacts with Glycine?
In the NutriStack database, Glycine has 6 documented interactions with other supplements and medications. The most notable include GABA, L-Methionine, L-Theanine, Magnesium Glycinate, and NAC.
What works well with Glycine?
Glycine pairs synergistically with GABA, L-Methionine, L-Theanine, Magnesium Glycinate, and NAC in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Glycine with GABA?
NutriStack classifies the Glycine and GABA pairing as synergy: Combining GABA with glycine layers two distinct inhibitory neurotransmitter systems, which can deepen overall central nervous system calming and support sleep onset. Reasonable to stack before bed (for example GABA 100 to 200mg with glycine 3g). Start low if also taking other sedatives and assess next-morning...
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See how glycine fits your routine.
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