Supplement·Interactions·Reviewed June 9, 2026
Gotu Kola interactions.
Gotu Kola has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Gotu Kola at a glance.
A quick, data-grounded summary. The full table is below.
Gotu Kola has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with gotu kola.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ashwagandha | Caution | Both are calming botanicals that may have additive sedative and central nervous system depressant effects, and both have isolated case reports... |
| Milk Thistle | Caution | Both Centella asiatica and milk thistle (silymarin) are botanicals with case-report associations to liver effects. Gotu kola has documented case... |
| St. John's Wort | Caution | St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein and is associated with photosensitivity, while gotu kola is metabolized hepatically... |
| L-Theanine | Synergy | Gotu kola has traditional and preliminary use for nervous tension, and L-theanine promotes a calm, alert state. Used together they may provide... |
| Vitamin C | Synergy | Vitamin C is an essential cofactor for prolyl and lysyl hydroxylase in collagen synthesis, while gotu kola triterpenoids stimulate fibroblast... |
The full gotu kola profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common gotu kola questions.
Quick answers drawn from the table above.
What interacts with Gotu Kola?
In the NutriStack database, Gotu Kola has 5 documented interactions with other supplements and medications. The most notable include Ashwagandha, Milk Thistle, St. John's Wort, L-Theanine, and Vitamin C.
What works well with Gotu Kola?
Gotu Kola pairs synergistically with L-Theanine and Vitamin C in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Gotu Kola with Ashwagandha?
NutriStack classifies the Gotu Kola and Ashwagandha pairing as caution: Both are calming botanicals that may have additive sedative and central nervous system depressant effects, and both have isolated case reports linking them to liver... Start low, watch for excess sedation especially if also using sleep aids or alcohol, and limit duration of combined use. Avoid before driving until...
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