Supplement·Interactions·Reviewed June 9, 2026
Grape Seed Extract interactions.
Grape Seed Extract has 8 documented interactions in the NutriStack database: 4 that need timing or caution and 4 that work synergistically. The full list, with what each pairing does, is below.
Grape Seed Extract at a glance.
A quick, data-grounded summary. The full table is below.
Grape Seed Extract has 8 documented interactions in the NutriStack database: 4 that need timing or caution and 4 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with grape seed extract.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ginkgo Biloba | Caution | Used together, grape seed extract and ginkgo may additively reduce platelet aggregation and impair clotting. For healthy people at usual supplement... |
| Nattokinase | Caution | Both can reduce platelet aggregation or affect clotting, so combining them may additively increase bleeding risk. |
| Warfarin | Caution | Grape seed extract contains procyanidins that inhibit platelet aggregation and prolong APTT and PT in vitro. A case report describes a stable... |
| Iron | Timing Sensitive | Taken at the same time as an iron supplement, grape seed extract can bind iron in the digestive tract and reduce how much is absorbed. The effect is... |
| Lisinopril | Synergy | Grape Seed Extract lowers blood pressure modestly (about 6 mm Hg systolic and 3 mm Hg diastolic in meta-analyses) through improved endothelial... details → |
| Pine Bark Extract | Synergy | Both are oligomeric proanthocyanidin sources with overlapping antioxidant and endothelial nitric-oxide-supporting effects, giving additive vascular... |
| Pomegranate Extract | Synergy | Both provide vascular polyphenols and may support endothelial function. |
| Vitamin C | Synergy | Vitamin C helps regenerate oxidized proanthocyanidin antioxidants, and the two together support endothelial and vascular antioxidant capacity. |
The full grape seed extract profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common grape seed extract questions.
Quick answers drawn from the table above.
What interacts with Grape Seed Extract?
In the NutriStack database, Grape Seed Extract has 8 documented interactions with other supplements and medications. The most notable include Ginkgo Biloba, Nattokinase, Warfarin, Iron, and Lisinopril.
What works well with Grape Seed Extract?
Grape Seed Extract pairs synergistically with Lisinopril, Pine Bark Extract, Pomegranate Extract, and Vitamin C in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Grape Seed Extract with Ginkgo Biloba?
NutriStack classifies the Grape Seed Extract and Ginkgo Biloba pairing as caution: Used together, grape seed extract and ginkgo may additively reduce platelet aggregation and impair clotting. For healthy people at usual supplement doses this is... If you take both, watch for easy bruising, nosebleeds, or prolonged bleeding from cuts. Stop both supplements at least 1 to 2 weeks before any...
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