Supplement·Interactions·Reviewed June 9, 2026
Green Tea Extract interactions.
Green Tea Extract has 41 documented interactions in the NutriStack database: 4 to avoid or watch closely, 32 that need timing or caution, and 5 that work synergistically. The full list, with what each pairing does, is below.
Green Tea Extract at a glance.
A quick, data-grounded summary. The full table is below.
Green Tea Extract has 41 documented interactions in the NutriStack database: 4 to avoid or watch closely, 32 that need timing or caution, and 5 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with green tea extract.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Atorvastatin | Conflict | Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced... details → |
| Iron | Conflict | Green tea catechins, particularly EGCG, bind non-heme iron in the gut, reducing absorption by up to 60-70%. This is one of the most potent dietary... details → |
| Rosuvastatin | Conflict | Repeated green tea extract significantly reduced systemic rosuvastatin exposure in healthy volunteers. This could reduce or unpredictably alter... details → |
| Warfarin | Conflict | Green tea contains vitamin K1 which can antagonize warfarin's anticoagulant effect. Concentrated green tea extract supplements provide substantially... details → |
| Berberine | Caution | Both can lower blood glucose, so combining them may produce an additive hypoglycemic effect, especially during fasting or when also taking... details → |
| Bergamot (Citrus Bergamia) Extract | Caution | Both can cause GI upset, and concentrated green tea extract has liver-injury concerns at high EGCG doses. |
| Bitter Melon | Caution | Both can cause GI upset, and concentrated extracts may add liver-safety uncertainty in susceptible people. |
| Black Cohosh | Caution | Concentrated Green Tea Extract is one of the botanicals most consistently linked to liver injury in the US Drug-Induced Liver Injury Network, and... |
| Caffeine | Caution | Many green tea extracts contain caffeine and concentrated EGCG, increasing stimulant and liver-safety concerns. |
| Cimetidine | Caution | Cimetidine inhibits CYP1A2, the main enzyme that clears caffeine. Caffeine-containing green tea extract taken with cimetidine can produce higher and... details → |
| Cinnamon Extract | Caution | Concentrated extracts can both cause GI upset, and cassia cinnamon plus high-dose EGCG may increase liver-safety concerns. |
| Ciprofloxacin | Caution | Ciprofloxacin inhibits CYP1A2, the same enzyme that metabolizes caffeine present in green tea extract. This inhibition can roughly double caffeine... details → |
| Ecdysterone | Caution | Stacking multiple concentrated performance extracts increases uncertainty around liver safety and product adulteration. |
| EGCG (Epigallocatechin Gallate) | Caution | EGCG is the principal catechin in green tea extract, so combining a standalone EGCG product with green tea extract stacks the same compound and... |
| Ellagic Acid | Caution | Both ellagic acid (and its ellagitannin-rich source extracts) and green tea extract are concentrated polyphenols. Stacking multiple high-dose... |
| Epicatechin | Caution | Both supply catechin-type polyphenols; high-dose stacks can increase GI and liver-safety concerns. |
| Famciclovir | Caution | Concentrated green tea catechins such as EGCG inhibit aldehyde oxidase in vitro, the same enzyme responsible for converting the prodrug famciclovir... |
| Felodipine | Caution | Green tea catechins can inhibit intestinal organic anion transporting polypeptides and may modestly affect CYP3A4 and P-glycoprotein, with the... |
| Fluvoxamine | Caution | Fluvoxamine is a potent CYP1A2 inhibitor, and the caffeine in green tea extracts is metabolized almost entirely by CYP1A2. In healthy volunteers,... details → |
| Fucoxanthin | Caution | Both are marketed for fat metabolism and may have additive effects on lipid oxidation and thermogenesis. The combination is not inherently harmful,... |
| HGH Fragment 176-191 | Caution | Weight-loss supplement stacking can increase adverse-effect burden while efficacy remains unproven. |
| Itraconazole | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Itraconazole. |
| Levodopa/Carbidopa | Caution | Green tea extract can contain concentrated EGCG and other catechins that inhibit catechol-O-methyltransferase in preclinical levodopa models. That... |
| Mucuna Pruriens | Caution | Caffeinated green tea extract can add stimulation and insomnia to dopaminergic mucuna effects. |
| Niacin (Prescription) | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Niacin (Prescription). |
| Niacinamide | Caution | High-dose niacinamide and concentrated green tea extract can both raise liver-safety concerns in susceptible users. |
| Noopept | Caution | Caffeinated green tea extract can add stimulation, anxiety, insomnia, or palpitations to a CNS-active nootropic. |
| Oligonol (Lychee Polyphenol) | Caution | Both Oligonol and green tea extract are concentrated polyphenol products; stacking high doses adds to total polyphenol and, with green tea, catechin... |
| Propranolol | Caution | Green tea extract contains caffeine, which propranolol blunts the cardiovascular response to, and vice versa. High-dose green tea extract can also... |
| Red Yeast Rice | Caution | Concentrated green tea extract can raise liver-injury risk, which may compound red yeast rice hepatotoxicity concerns. |
| Roflumilast | Caution | Caffeinated green tea extract may compound roflumilast-associated insomnia, anxiety, tremor, or appetite suppression. |
| Salmeterol/Fluticasone | Caution | Caffeinated green tea extract may add to salmeterol-related tremor, palpitations, and insomnia. |
| Theacrine | Caution | Green tea extract may contain caffeine, creating additive stimulant effects with theacrine. |
| Theophylline | Caution | Caffeinated green tea extract can add to methylxanthine stimulation and may worsen tremor, insomnia, tachycardia, nausea, and arrhythmia risk. |
| Voriconazole | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Voriconazole. |
| Fexofenadine | Timing Sensitive | Green tea extract can sharply reduce fexofenadine absorption when taken together. In a randomized crossover study, an EGCG-rich green tea extract... details → |
| CLA | Synergy | CLA and green tea extract are often combined for body composition support and may have complementary effects on fat oxidation and energy expenditure. |
| Ergothioneine | Synergy | Green tea catechins and ergothioneine are both dietary antioxidants with anti-inflammatory activity that can act through complementary mechanisms. |
| L-Theanine | Synergy | L-theanine smooths the caffeine stimulation from green tea extract, improving sustained attention while reducing jitteriness and the post-caffeine... |
| Luteolin | Synergy | Luteolin and green tea catechins (notably EGCG) share antioxidant and anti-inflammatory polyphenol activity and may provide additive support, though... |
| Quercetin | Synergy | Quercetin may raise plasma levels of green tea catechins by slowing their breakdown, and the two polyphenols provide additive antioxidant and... |
The full green tea extract profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common green tea extract questions.
Quick answers drawn from the table above.
What interacts with Green Tea Extract?
In the NutriStack database, Green Tea Extract has 41 documented interactions with other supplements and medications. The most notable include Atorvastatin, Iron, Rosuvastatin, Warfarin, and Berberine.
What should you not take with Green Tea Extract?
Green Tea Extract is flagged against 4 substances in the database, including Atorvastatin, Iron, Rosuvastatin, and Warfarin. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Green Tea Extract?
Green Tea Extract pairs synergistically with CLA, Ergothioneine, L-Theanine, Luteolin, and Quercetin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Green Tea Extract with Atorvastatin?
NutriStack classifies the Green Tea Extract and Atorvastatin pairing as conflict: Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced absorption rather than... Avoid taking concentrated green tea extract at the same time as atorvastatin. If you use green tea extract regularly, keep the routine consistent...
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