Supplement·Interactions·Reviewed June 9, 2026
Iodine interactions.
Iodine has 12 documented interactions in the NutriStack database: 7 that need timing or caution and 5 that work synergistically. The full list, with what each pairing does, is below.
Iodine at a glance.
A quick, data-grounded summary. The full table is below.
Iodine has 12 documented interactions in the NutriStack database: 7 that need timing or caution and 5 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with iodine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Acetyl-L-Carnitine | Caution | Acetyl-L-Carnitine and Iodine pull on thyroid physiology in opposing directions. Iodine is taken to supply substrate for thyroid hormone production,... |
| Amiodarone | Caution | Amiodarone contains a large iodine load and is strongly associated with thyroid dysfunction. Extra iodine from supplements can further increase... details → |
| Ashwagandha | Caution | Ashwagandha may stimulate thyroid hormone production (T4 and T3) via its effects on the HPA axis and direct thyroid stimulation. Combined with... |
| Lithium | Caution | Lithium concentrates in the thyroid and inhibits thyroid hormone synthesis. Iodine supplementation in lithium-treated patients can worsen... details → |
| Lithium Orotate | Caution | Lithium and iodine both affect the thyroid gland, and using them together can increase the likelihood of hypothyroidism or goiter through compounded... details → |
| Methimazole | Caution | Iodine intake can change how Graves' disease responds to methimazole. High or unstable iodine exposure can alter thyroid hormone synthesis and may... details → |
| Moringa | Caution | Moringa is a mild goitrogen: its glucosinolate-derived thiocyanate competes with iodide at the same thyroid transporter (NIS), so it can partially... |
| Iron | Synergy | Iron deficiency impairs thyroid hormone synthesis because thyroid peroxidase (TPO) is a heme-containing enzyme. |
| Iron Bisglycinate | Synergy | Iron Bisglycinate deficiency impairs thyroid hormone synthesis because thyroid peroxidase (TPO) is a heme-containing enzyme. |
| L-Tyrosine | Synergy | Iodine and L-tyrosine are the two raw materials the thyroid combines to build thyroid hormone, so adequacy of both supports normal hormone synthesis. |
| Selenium | Synergy | Selenium is critical for thyroid hormone metabolism. Selenoproteins (deiodinases) convert T4 to active T3, and glutathione peroxidase protects the... details → |
| Zinc | Synergy | Adequate zinc is needed for thyroid hormone synthesis and signaling, so zinc supports the thyroid effects of iodine. |
The full iodine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common iodine questions.
Quick answers drawn from the table above.
What interacts with Iodine?
In the NutriStack database, Iodine has 12 documented interactions with other supplements and medications. The most notable include Acetyl-L-Carnitine, Amiodarone, Ashwagandha, Lithium, and Lithium Orotate.
What works well with Iodine?
Iodine pairs synergistically with Iron, Iron Bisglycinate, L-Tyrosine, Selenium, and Zinc in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Iodine with Acetyl-L-Carnitine?
NutriStack classifies the Iodine and Acetyl-L-Carnitine pairing as caution: Acetyl-L-Carnitine and Iodine pull on thyroid physiology in opposing directions. Iodine is taken to supply substrate for thyroid hormone production, whereas... For most people taking modest Iodine for general nutritional support, this is a mild theoretical concern. People with hypothyroidism, those actively...
Check your whole stack
See how iodine fits your routine.
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