Supplement·Interactions·Reviewed June 9, 2026
L-Citrulline interactions.
L-Citrulline has 32 documented interactions in the NutriStack database: 1 to avoid or watch closely, 22 that need timing or caution, and 9 that work synergistically. The full list, with what each pairing does, is below.
L-Citrulline at a glance.
A quick, data-grounded summary. The full table is below.
L-Citrulline has 32 documented interactions in the NutriStack database: 1 to avoid or watch closely, 22 that need timing or caution, and 9 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with l-citrulline.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Citrulline Malate | Conflict | Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects. |
| Agmatine Sulfate | Caution | Both affect nitric oxide or vascular pathways, but agmatine may modulate nitric oxide synthase unpredictably. |
| Alfuzosin | Caution | L-Citrulline increases systemic arginine availability and can modestly lower blood pressure. Alfuzosin can also contribute to blood-pressure... details → |
| Amlodipine | Caution | L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than oral arginine itself, producing nitric-oxide-mediated... details → |
| Candesartan | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Candesartan. |
| Captopril | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Captopril. |
| Chlorthalidone | Caution | L-Citrulline can modestly lower blood pressure through the arginine-nitric oxide pathway. Chlorthalidone has sustained antihypertensive and diuretic... details → |
| D-Aspartic Acid | Caution | L-Citrulline is one of the most common nitric oxide boosters in pre-workout and pump products, and it reliably elevates plasma arginine and nitric... |
| Felodipine | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Felodipine. |
| Hydrochlorothiazide | Caution | L-Citrulline can increase arginine availability and modestly lower systolic blood pressure. Hydrochlorothiazide also lowers blood pressure, so the... details → |
| Isosorbide Mononitrate | Caution | L-citrulline increases L-arginine availability and can lower blood pressure through nitric oxide pathways. Isosorbide mononitrate is an organic... details → |
| Labetalol | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Labetalol. |
| Metoprolol | Caution | L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than arginine itself, producing nitric-oxide-mediated... details → |
| Nebivolol | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Nebivolol. |
| Nitroglycerin | Caution | L-citrulline raises circulating L-arginine and can support nitric-oxide-mediated blood pressure lowering. Nitroglycerin also works through nitric... details → |
| Pentadeca Arginate (PDA) | Caution | PDA is marketed as an arginate salt and related BPC-157 animal data involve nitric oxide pathways; L-citrulline can raise nitric oxide availability. |
| Perindopril | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Perindopril. |
| Quinapril | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Quinapril. |
| Silodosin | Caution | L-citrulline can increase nitric oxide availability and may add to silodosin-related dizziness or orthostatic hypotension. |
| Tamsulosin | Caution | L-Citrulline raises plasma arginine and can lower blood pressure through nitric-oxide-mediated vasodilation. Tamsulosin has a documented association... details → |
| Telmisartan | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Telmisartan. |
| Timolol Ophthalmic | Caution | L-Citrulline increases arginine availability and can modestly lower blood pressure. Timolol eye drops can reach systemic circulation and produce... details → |
| VIP (Vasoactive Intestinal Peptide) | Caution | L-citrulline can increase nitric oxide-mediated vasodilation and may add to VIP-related flushing or low blood pressure. |
| Beetroot Extract (Dietary Nitrate) | Synergy | Both increase nitric oxide availability and may additively lower blood pressure. |
| Beta-Alanine | Synergy | Beta-alanine and L-citrulline are frequently combined and may give complementary gains in high-intensity and endurance performance. |
| L-Arginine | Synergy | Citrulline is converted to arginine in the kidney, raising plasma arginine higher and longer than oral arginine alone. Combined use provides... |
| Lisinopril | Synergy | L-Citrulline is converted to arginine in the kidney and produces sustained increases in nitric oxide. A meta-analysis of clinical trials reported... details → |
| Oligonol (Lychee Polyphenol) | Synergy | L-Citrulline raises plasma arginine and nitric oxide production while Oligonol supports endothelial function and microcirculation; combined use may... |
| Pine Bark Extract | Synergy | L-citrulline raises plasma arginine and nitric oxide production, complementing pine bark extract's enhancement and protection of endothelial nitric... |
| Sildenafil | Synergy | L-Citrulline can increase L-arginine availability and nitric-oxide-dependent signaling, which is upstream of sildenafil's PDE5 effect. In a small... |
| Tadalafil | Synergy | L-Citrulline can raise plasma L-arginine and nitric-oxide signaling, while tadalafil preserves cGMP by inhibiting PDE5. A small randomized crossover... |
| Taurine | Synergy | Both amino acids support endothelial function and exercise performance, and are commonly combined for complementary vascular and ergogenic effects. |
The full l-citrulline profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common l-citrulline questions.
Quick answers drawn from the table above.
What interacts with L-Citrulline?
In the NutriStack database, L-Citrulline has 32 documented interactions with other supplements and medications. The most notable include Citrulline Malate, Agmatine Sulfate, Alfuzosin, Amlodipine, and Candesartan.
What should you not take with L-Citrulline?
L-Citrulline is flagged against 1 substance in the database, including Citrulline Malate. Review these with a clinician before combining, especially alongside prescription medications.
What works well with L-Citrulline?
L-Citrulline pairs synergistically with Beetroot Extract (Dietary Nitrate), Beta-Alanine, L-Arginine, Lisinopril, and Oligonol (Lychee Polyphenol) in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take L-Citrulline with Citrulline Malate?
NutriStack classifies the L-Citrulline and Citrulline Malate pairing as conflict: Citrulline malate already supplies citrulline, so adding L-citrulline can create duplicate high dosing and GI effects. Count total citrulline from all products and reduce doses if stacking.
Check your whole stack
See how l-citrulline fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.