Supplement·Interactions·Reviewed June 9, 2026
Lithium Orotate interactions.
Lithium Orotate has 12 documented interactions in the NutriStack database: 1 to avoid or watch closely and 11 that need timing or caution. The full list, with what each pairing does, is below.
Lithium Orotate at a glance.
A quick, data-grounded summary. The full table is below.
Lithium Orotate has 12 documented interactions in the NutriStack database: 1 to avoid or watch closely and 11 that need timing or caution. The full list, with what each pairing does, is below.
Everything that interacts with lithium orotate.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Psilocybin | Contraindicated | Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological... |
| Benazepril | Caution | Benazepril is an ACE inhibitor that reduces sodium reabsorption and lowers glomerular filtration. This causes the kidney to retain lithium and... details → |
| Enalapril | Caution | Enalapril reduces sodium reabsorption and lowers glomerular filtration, which causes the kidney to retain lithium and pushes serum lithium levels... details → |
| Inositol | Caution | Inositol counteracts part of lithium's proposed mechanism by replenishing the inositol pool that lithium depletes, which may blunt lithium's... |
| Iodine | Caution | Lithium and iodine both affect the thyroid gland, and using them together can increase the likelihood of hypothyroidism or goiter through compounded... details → |
| Irbesartan | Caution | Irbesartan blocks the AT1 receptor, reduces sodium reabsorption, and increases lithium retention by the kidney. Multiple published cases with ARBs... details → |
| Losartan | Caution | Losartan blocks the AT1 receptor and reduces sodium reabsorption, which causes the kidney to retain lithium. A published case described a previously... details → |
| Olmesartan | Caution | Olmesartan blocks the AT1 receptor, reduces sodium reabsorption, and increases lithium retention by the kidney. Multiple case reports with ARBs... details → |
| Ramipril | Caution | Ramipril reduces sodium reabsorption and lowers glomerular filtration, which causes the kidney to retain lithium. Case reports with ACE inhibitors... details → |
| Sacubitril/Valsartan | Caution | The valsartan component blocks AT1 receptors, reduces sodium reabsorption, and increases lithium retention by the kidney. A published case described... details → |
| Valsartan | Caution | Valsartan reduces sodium reabsorption through AT1 receptor blockade and lowers glomerular filtration, which causes the kidney to retain lithium.... details → |
| Psyllium Husk | Timing Sensitive | Taking psyllium husk concurrently with lithium orotate can blunt lithium absorption and lower its effective dose. This is supported by a documented... |
The full lithium orotate profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common lithium orotate questions.
Quick answers drawn from the table above.
What interacts with Lithium Orotate?
In the NutriStack database, Lithium Orotate has 12 documented interactions with other supplements and medications. The most notable include Psilocybin, Benazepril, Enalapril, Inositol, and Iodine.
What should you not take with Lithium Orotate?
Lithium Orotate is flagged against 1 substance in the database, including Psilocybin. Review these with a clinician before combining, especially alongside prescription medications.
Can you take Lithium Orotate with Psilocybin?
NutriStack classifies the Lithium Orotate and Psilocybin pairing as contraindicated: Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological reactions, making this... Do not combine. If you take any lithium-containing product, do not use psilocybin and seek medical advice.
Check your whole stack
See how lithium orotate fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.