Supplement·Interactions·Reviewed June 9, 2026
Luteolin interactions.
Luteolin has 4 documented interactions in the NutriStack database: 1 that need timing or caution and 3 that work synergistically. The full list, with what each pairing does, is below.
Luteolin at a glance.
A quick, data-grounded summary. The full table is below.
Luteolin has 4 documented interactions in the NutriStack database: 1 that need timing or caution and 3 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with luteolin.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Caution | Luteolin inhibits several cytochrome P450 enzymes (including CYP3A4 and CYP1A2) and drug transporters, whereas St. John's Wort is a potent inducer... |
| Curcumin Phytosome | Synergy | Luteolin and curcumin both suppress NF-kappaB-driven inflammation and microglial activation, providing complementary anti-inflammatory and... |
| Green Tea Extract | Synergy | Luteolin and green tea catechins (notably EGCG) share antioxidant and anti-inflammatory polyphenol activity and may provide additive support, though... |
| Quercetin | Synergy | Luteolin and quercetin are both flavonoids with overlapping mast-cell-stabilizing, antihistaminic, and NF-kappaB-inhibiting anti-inflammatory... |
The full luteolin profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common luteolin questions.
Quick answers drawn from the table above.
What interacts with Luteolin?
In the NutriStack database, Luteolin has 4 documented interactions with other supplements and medications. The most notable include St. John's Wort, Curcumin Phytosome, Green Tea Extract, and Quercetin.
What works well with Luteolin?
Luteolin pairs synergistically with Curcumin Phytosome, Green Tea Extract, and Quercetin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Luteolin with St. John's Wort?
NutriStack classifies the Luteolin and St. John's Wort pairing as caution: Luteolin inhibits several cytochrome P450 enzymes (including CYP3A4 and CYP1A2) and drug transporters, whereas St. John's Wort is a potent inducer of CYP3A4 and... Avoid relying on this combination to manage any medication regimen. Anyone on St. John's Wort for mood should consult a clinician before adding...
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