Supplement·Interactions·Reviewed June 9, 2026
Lycopene interactions.
Lycopene has 8 documented interactions in the NutriStack database: 2 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Lycopene at a glance.
A quick, data-grounded summary. The full table is below.
Lycopene has 8 documented interactions in the NutriStack database: 2 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with lycopene.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Aspirin Low-Dose | Caution | Lycopene has antiplatelet activity in platelet studies, and an in vitro human platelet study directly evaluated lycopene with aspirin and found... |
| Beta-Carotene | Timing Sensitive | Taking beta-carotene and lycopene together in the same dose reduces the short-term absorption of each, because they compete for the same fat-based... |
| Evening Primrose Oil | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Lycopene. |
| Flaxseed Oil | Synergy | Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Lycopene. |
| MCT Oil | Synergy | MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Lycopene. |
| Saw Palmetto | Synergy | Lycopene and saw palmetto are frequently combined for prostate health, and combination trials suggest complementary benefit for benign prostatic... |
| Selenium | Synergy | Lycopene and selenium have complementary antioxidant actions and have been studied together for prostate health and as antioxidant combinations. |
| Vitamin E | Synergy | Lycopene and vitamin E are lipid-soluble antioxidants that work together in cell membranes and lipoproteins, with vitamin E helping spare and... |
The full lycopene profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common lycopene questions.
Quick answers drawn from the table above.
What interacts with Lycopene?
In the NutriStack database, Lycopene has 8 documented interactions with other supplements and medications. The most notable include Aspirin Low-Dose, Beta-Carotene, Evening Primrose Oil, Flaxseed Oil, and MCT Oil.
What works well with Lycopene?
Lycopene pairs synergistically with Evening Primrose Oil, Flaxseed Oil, MCT Oil, Saw Palmetto, and Selenium in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Lycopene with Aspirin Low-Dose?
NutriStack classifies the Lycopene and Aspirin Low-Dose pairing as caution: Lycopene has antiplatelet activity in platelet studies, and an in vitro human platelet study directly evaluated lycopene with aspirin and found additive inhibition of... Use lycopene supplements cautiously with low-dose aspirin, especially if you also take anticoagulants, clopidogrel, NSAIDs, SSRIs/SNRIs, or have a...
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