Supplement·Interactions·Reviewed June 9, 2026
Maca Root interactions.
Maca Root has 7 documented interactions in the NutriStack database: 2 that need timing or caution and 5 that work synergistically. The full list, with what each pairing does, is below.
Maca Root at a glance.
A quick, data-grounded summary. The full table is below.
Maca Root has 7 documented interactions in the NutriStack database: 2 that need timing or caution and 5 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with maca root.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Estradiol | Caution | Maca has been used for menopausal symptoms and sexual function with modest positive findings in small trials, and does not contain phytoestrogens.... |
| Testosterone | Caution | Maca (Lepidium meyenii) has shown benefits for libido and sexual function in small trials but does not raise serum testosterone. It is generally... |
| DHEA | Synergy | Maca improves subjective sexual function without changing hormones; DHEA raises androgens. Combined use can support both subjective and hormonal... |
| Ginkgo Biloba | Synergy | The pair combines Maca's effect on sexual desire with Ginkgo's influence on peripheral blood flow and nitric oxide, offering complementary support... |
| L-Arginine | Synergy | The pair approaches sexual function from two angles, with Maca acting on libido and sexual desire while L-Arginine supports the nitric oxide pathway... |
| Tongkat Ali | Synergy | Maca improves subjective libido without changing hormones; tongkat ali raises testosterone. Combined use targets both subjective and hormonal... |
| Tribulus Terrestris | Synergy | Combining Tribulus and Maca pairs two libido and sexual function botanicals that act through largely separate pathways, giving complementary support... |
The full maca root profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common maca root questions.
Quick answers drawn from the table above.
What interacts with Maca Root?
In the NutriStack database, Maca Root has 7 documented interactions with other supplements and medications. The most notable include Estradiol, Testosterone, DHEA, Ginkgo Biloba, and L-Arginine.
What works well with Maca Root?
Maca Root pairs synergistically with DHEA, Ginkgo Biloba, L-Arginine, Tongkat Ali, and Tribulus Terrestris in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Maca Root with Estradiol?
NutriStack classifies the Maca Root and Estradiol pairing as caution: Maca has been used for menopausal symptoms and sexual function with modest positive findings in small trials, and does not contain phytoestrogens. It is generally... If menopausal symptoms persist on prescribed estradiol, maca 1.5-3 g/day may be tried with prescriber awareness. Maca does not raise serum...
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