Supplement·Interactions·Reviewed June 9, 2026
Magnesium Citrate interactions.
Magnesium Citrate has 27 documented interactions in the NutriStack database: 12 that need timing or caution and 15 that work synergistically. The full list, with what each pairing does, is below.
Magnesium Citrate at a glance.
A quick, data-grounded summary. The full table is below.
Magnesium Citrate has 27 documented interactions in the NutriStack database: 12 that need timing or caution and 15 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with magnesium citrate.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Amlodipine | Caution | Magnesium acts as a physiologic calcium-channel modulator and lowers blood pressure by about 2 mmHg systolic and 1.8 mmHg diastolic at supplemental... details → |
| Bisacodyl | Caution | Bisacodyl and magnesium citrate are both laxatives, and combining them can produce a stronger cathartic effect than either alone. Human... details → |
| Diltiazem | Caution | Magnesium is a physiologic calcium antagonist that lowers blood pressure by about 2/1.8 mmHg at supplemental doses and also blunts sinoatrial and... details → |
| Nifedipine | Caution | Magnesium is a physiologic calcium-channel modulator that lowers blood pressure by about 2 mmHg systolic at supplemental doses. Combined with... details → |
| Calcium | Timing Sensitive | High-dose calcium and magnesium compete for absorption when taken simultaneously. details → |
| Ciprofloxacin | Timing Sensitive | Magnesium citrate, like other magnesium salts, chelates ciprofloxacin in the gut and reduces its absorption. Single-dose studies have shown... details → |
| Doxycycline | Timing Sensitive | Magnesium citrate releases Mg2+ that chelates doxycycline in the gut and reduces antibiotic absorption. The interaction applies to all magnesium... details → |
| Gabapentin | Timing Sensitive | Magnesium can reduce gabapentin absorption when taken at the same time. A controlled pharmacokinetic study using magnesium oxide found substantially... details → |
| Iron | Timing Sensitive | Magnesium and iron can compete for absorption when taken together. Separate for optimal absorption of both. |
| Levothyroxine | Timing Sensitive | Magnesium-containing products can interfere with levothyroxine absorption when taken together. The best evidence is for magnesium antacids and other... |
| Manganese | Timing Sensitive | Taking a large magnesium dose at the same time as manganese may slightly reduce manganese absorption through general divalent-mineral interference... |
| Strontium | Timing Sensitive | Strontium and magnesium taken in the same dose can compete for absorption because both move across the gut as divalent cations using overlapping... |
| Apigenin | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Ashwagandha | Synergy | Both promote relaxation and support sleep quality through complementary mechanisms. |
| Chlorthalidone | Synergy | Chlorthalidone can cause magnesium depletion during long-term treatment. Magnesium citrate may help replenish magnesium, particularly when potassium... details → |
| Citalopram | Synergy | Citalopram produces dose-dependent QT interval prolongation and carries a black-box warning at doses above 40 mg/day (or 20 mg in older adults).... details → |
| Creatine | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Furosemide | Synergy | Furosemide can increase urinary magnesium loss during chronic therapy. Magnesium citrate may help replete magnesium when levels are low, but... details → |
| Hydrochlorothiazide | Synergy | Hydrochlorothiazide can increase renal magnesium excretion during chronic therapy. Magnesium citrate may help replace magnesium if levels fall, and... details → |
| L-Theanine | Synergy | L-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited. |
| Lisinopril | Synergy | Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic and 2 mm Hg diastolic reductions in... details → |
| Losartan | Synergy | Magnesium supplementation lowers blood pressure modestly (about 2-3 mm Hg systolic and 2 mm Hg diastolic) when added to antihypertensive medication.... details → |
| Melatonin | Synergy | Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary. |
| Potassium | Synergy | Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize. details → |
| Vitamin B1 | Synergy | Magnesium is required for thiamine (B1) utilization. Magnesium deficiency impairs thiamine-dependent enzyme activity. |
| Vitamin B6 | Synergy | Vitamin B6 increases intracellular magnesium accumulation. Magnesium is required for B6 activation to its coenzyme form PLP. |
| Vitamin D3 | Synergy | Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol. details → |
The full magnesium citrate profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common magnesium citrate questions.
Quick answers drawn from the table above.
What interacts with Magnesium Citrate?
In the NutriStack database, Magnesium Citrate has 27 documented interactions with other supplements and medications. The most notable include Amlodipine, Bisacodyl, Diltiazem, Nifedipine, and Calcium.
What works well with Magnesium Citrate?
Magnesium Citrate pairs synergistically with Apigenin, Ashwagandha, Chlorthalidone, Citalopram, and Creatine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Magnesium Citrate with Amlodipine?
NutriStack classifies the Magnesium Citrate and Amlodipine pairing as caution: Magnesium acts as a physiologic calcium-channel modulator and lowers blood pressure by about 2 mmHg systolic and 1.8 mmHg diastolic at supplemental elemental-magnesium... If you take amlodipine, magnesium citrate doses of 200-350 mg/day supplemental elemental magnesium are usually safe but check your blood pressure...
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