Supplement·Interactions·Reviewed June 9, 2026
Magnesium Glycinate interactions.
Magnesium Glycinate has 98 documented interactions in the NutriStack database: 56 that need timing or caution and 42 that work synergistically. The full list, with what each pairing does, is below.
In short
Magnesium Glycinate at a glance.
A quick, data-grounded summary. The full table is below.
Magnesium Glycinate has 98 documented interactions in the NutriStack database: 56 that need timing or caution and 42 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with magnesium glycinate.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Amlodipine | Caution | Both amlodipine and magnesium act as calcium channel blockers through related mechanisms, creating additive hypotensive effects. Amlodipine blocks... details → |
| Calcitriol | Caution | Magnesium supplements can contribute to hypermagnesemia in advanced kidney disease, and calcitriol is often used in kidney-related mineral disorders. |
| Candesartan | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Candesartan. |
| Captopril | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Captopril. |
| Cinacalcet | Caution | Low magnesium can worsen neuromuscular irritability and arrhythmia risk when hypocalcemia occurs, but supplementation in kidney disease requires... |
| Clonidine | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Clonidine. |
| Digoxin | Caution | Hypomagnesemia increases sensitivity to digoxin toxicity by altering the cardiac sodium-potassium ATPase that digoxin inhibits. Maintaining adequate... details → |
| Esomeprazole | Caution | Long-term esomeprazole use can cause hypomagnesemia, sometimes severe enough to trigger tetany, seizures, or arrhythmia. The FDA has issued a class... details → |
| Famciclovir | Caution | Famciclovir absorption is not dependent on gastric acidity and it does not chelate divalent cations in a clinically significant way, so magnesium... |
| Felodipine | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Felodipine. |
| Galantamine | Caution | Magnesium can loosen stools, while galantamine commonly causes nausea, vomiting, and diarrhea. |
| Hydroxychloroquine | Caution | Hydroxychloroquine can prolong QTc, and low magnesium makes torsades de pointes more likely when QT risk factors stack. Magnesium supplementation... details → |
| Inulin | Caution | Both can change bowel habits; magnesium can loosen stools while inulin increases fermentation. |
| Ivabradine | Caution | Ivabradine can cause clinically important bradycardia, and torsades de pointes has been reported when interacting QT-risk drugs are added. Low... |
| Labetalol | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Labetalol. |
| Lacosamide | Caution | Usual magnesium doses are not a direct problem, but very high magnesium exposure in renal impairment can worsen weakness or cardiac conduction... |
| Lansoprazole | Caution | Lansoprazole, like other PPIs, can cause hypomagnesemia after months to years of use. Case reports and meta-analyses confirm reduced intestinal... details → |
| Lithium | Caution | Magnesium may affect lithium excretion and distribution, as both are divalent cations handled by similar renal transport mechanisms. Changes in... |
| Nebivolol | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Nebivolol. |
| Omeprazole | Caution | Long-term omeprazole use (>1 year) has been associated with clinically significant magnesium depletion (hypomagnesemia). The FDA issued a safety... details → |
| Ondansetron | Caution | Ondansetron can prolong the QT interval and rare cases of torsades de pointes have been reported, especially with IV dosing or predisposing risks.... details → |
| Pantoprazole | Caution | Long-term pantoprazole use can cause hypomagnesemia, similar to other PPIs. The FDA warning about PPI-induced magnesium depletion applies to all... details → |
| Partially Hydrolyzed Guar Gum (Sunfiber) | Caution | Both can affect bowel habits; magnesium may loosen stools while PHGG changes stool water and fermentation. |
| Peppermint Oil (Enteric-Coated) | Caution | Magnesium can loosen stool while peppermint oil relaxes smooth muscle, potentially increasing diarrhea or urgency in sensitive users. |
| Perindopril | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Perindopril. |
| Quinapril | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Quinapril. |
| Rivastigmine | Caution | Magnesium can loosen stools, while rivastigmine commonly causes nausea, vomiting, and diarrhea. |
| Telmisartan | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Telmisartan. |
| Tenofovir Disoproxil | Caution | Tenofovir disoproxil can cause proximal renal tubular dysfunction (a Fanconi-like syndrome) that produces urinary wasting of phosphate, potassium,... |
| Vancomycin | Caution | Intravenous vancomycin is nephrotoxic, particularly at high troughs or with prolonged courses, and renal impairment alters the clearance and balance... |
| Verapamil | Caution | Both verapamil and magnesium block calcium channels. Combined use can cause excessive bradycardia, hypotension, and AV conduction delay. details → |
| VIP (Vasoactive Intestinal Peptide) | Caution | Magnesium can lower blood pressure in some users and may add to VIP-related dizziness. |
| Alendronate | Timing Sensitive | Magnesium can chelate alendronate, reducing its absorption. While the interaction is similar in mechanism to calcium and iron, alendronate's... details → |
| Calcium | Timing Sensitive | High-dose calcium and magnesium compete for absorption when taken simultaneously. details → |
| Cefdinir | Timing Sensitive | Magnesium Glycinate can reduce oral Cefdinir absorption when taken together. |
| Cefpodoxime | Timing Sensitive | Magnesium-containing supplements and antacids can reduce cefpodoxime absorption. Magnesium hydroxide antacids in particular raise gastric pH, and... |
| Ciprofloxacin | Timing Sensitive | Magnesium chelates ciprofloxacin, forming insoluble complexes that substantially reduce antibiotic absorption. Magnesium-containing antacids are... details → |
| Doxycycline | Timing Sensitive | Magnesium chelates doxycycline, reducing its absorption and potentially compromising treatment efficacy. Magnesium-containing antacids are... details → |
| Fosfomycin | Timing Sensitive | Magnesium is a divalent cation that can chelate fosfomycin within the gut, similar to the documented interaction with magnesium-containing antacids.... |
| Gabapentin | Timing Sensitive | Magnesium-containing antacids and supplements reduce gabapentin absorption when taken concurrently. Studies have shown approximately 20% reduction... details → |
| Glycerol | Timing Sensitive | Magnesium and glycerol can both cause GI looseness in some users near exercise. |
| Ibandronate | Timing Sensitive | Magnesium can bind oral ibandronate and reduce its already very low bioavailability. |
| Iron | Timing Sensitive | Magnesium and iron can compete for absorption when taken together. Separate for optimal absorption of both. |
| Iron Bisglycinate | Timing Sensitive | Magnesium and iron bisglycinate can compete for absorption when taken together. Separate for optimal absorption of both. |
| Levofloxacin | Timing Sensitive | Magnesium glycinate chelates levofloxacin in the gut, dramatically reducing antibiotic absorption. The bioavailability decrease can exceed 40... details → |
| Levothyroxine | Timing Sensitive | Magnesium supplements, particularly magnesium oxide and magnesium hydroxide (antacid forms), can reduce levothyroxine absorption by forming chelate... details → |
| Minocycline | Timing Sensitive | Magnesium Glycinate can reduce oral Minocycline absorption when taken together. |
| Moxifloxacin | Timing Sensitive | Magnesium Glycinate can reduce oral Moxifloxacin absorption when taken together. |
| Mycophenolate Mofetil | Timing Sensitive | Magnesium/aluminum antacids can reduce mycophenolate absorption and lower mycophenolic acid exposure; ordinary magnesium supplements are less... |
| Nitrofurantoin | Timing Sensitive | Magnesium-containing antacids and supplements have been shown to reduce nitrofurantoin absorption, an effect first demonstrated for magnesium... details → |
| Risedronate | Timing Sensitive | Magnesium is a divalent cation that chelates risedronate in the gut lumen and prevents it from being absorbed. Studies of mineral water rich in... details → |
| Sodium Bicarbonate | Timing Sensitive | Both can cause GI symptoms in some users, especially near training. |
| Sodium Butyrate | Timing Sensitive | Both supplements can loosen stools at higher intakes, magnesium via an osmotic effect and butyrate via effects on bowel habit. Taken together at... |
| Sucralfate | Timing Sensitive | Magnesium products may interfere with sucralfate binding behavior and can reduce the predictability of other oral drug absorption. |
| Tetracycline | Timing Sensitive | Magnesium Glycinate can reduce oral Tetracycline absorption when taken together. |
| Zinc | Timing Sensitive | High-dose zinc and high-dose magnesium can compete at intestinal divalent cation transporters; effect is significant only at supplemental doses... |
| Amiodarone | Synergy | Amiodarone can prolong cardiac repolarization, and low magnesium makes torsades de pointes more likely. Maintaining normal magnesium status helps... details → |
| Apigenin | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Ashwagandha | Synergy | Both promote relaxation and support sleep quality through complementary mechanisms. |
| Boron | Synergy | Boron has been shown to reduce urinary magnesium loss and raise serum magnesium, supporting magnesium status when the two are taken together. |
| Chlorthalidone | Synergy | Long-term chlorthalidone therapy can lower magnesium as well as potassium. Magnesium glycinate may help replace magnesium when levels are low or... details → |
| Chromium | Synergy | Chromium and magnesium each support insulin signaling, so adequate status of both is associated with better insulin sensitivity than low status of... |
| Combined Oral Contraceptive | Synergy | Combined oral contraceptive use is associated with lower serum magnesium and altered mineral status in observational studies, contributing to... details → |
| Creatine | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| Cyclosporine | Synergy | Magnesium may help correct cyclosporine-associated hypomagnesemia, but kidney function and levels must guide dosing. |
| D-Aspartic Acid | Synergy | Magnesium status is linked to testosterone, so magnesium glycinate may complement D-aspartic acid in supporting the androgen axis, especially where... |
| Dofetilide | Synergy | Dofetilide can cause torsades de pointes, and low magnesium is a recognized risk factor. Maintaining normal magnesium helps reduce susceptibility to... details → |
| Fluconazole | Synergy | Fluconazole can prolong the QT interval, especially at higher doses, in renal impairment, or with other QT-prolonging drugs. Low magnesium and low... details → |
| Furosemide | Synergy | Furosemide depletes magnesium through its action on the thick ascending limb, where the majority of magnesium reabsorption occurs. Loop... details → |
| GABA | Synergy | Magnesium glycinate complements oral GABA by supporting GABAergic tone, contributing to a calmer state and easier sleep onset. |
| Glycine | Synergy | Magnesium glycinate already contains glycine as its chelation partner. Additional glycine further supports sleep and inhibitory neurotransmission. |
| Haloperidol | Synergy | Magnesium deficiency can worsen torsades risk in patients receiving QT-prolonging drugs such as haloperidol. |
| Hydrochlorothiazide | Synergy | HCTZ increases renal magnesium excretion, and chronic use can lead to hypomagnesemia. Magnesium depletion can worsen potassium depletion (refractory... details → |
| Insulin Glargine | Synergy | Magnesium repletion may gradually improve insulin signaling and glucose control when magnesium status is low. Because insulin glargine provides... details → |
| L-Theanine | Synergy | L-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited. |
| Losartan/Hydrochlorothiazide | Synergy | Losartan/Hydrochlorothiazide can lower magnesium in some patients, and magnesium replacement may be needed when deficiency is documented. |
| Medroxyprogesterone | Synergy | Magnesium plays a structural and signaling role in bone health and supports the calcium-vitamin D-PTH axis. Although direct DMPA trials are limited,... |
| Melatonin | Synergy | Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary. |
| Metformin | Synergy | Magnesium is a cofactor for insulin receptor signaling and low intracellular magnesium contributes to insulin resistance, a problem common in type 2... details → |
| Metoprolol | Synergy | Magnesium acts as a natural calcium channel blocker and can enhance the blood pressure-lowering and heart rate-reducing effects of metoprolol... details → |
| Paliperidone | Synergy | Magnesium deficiency can worsen QT-related arrhythmia risk in patients taking QT-affecting antipsychotics. |
| Potassium | Synergy | Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize. details → |
| Pregnenolone | Synergy | Pregnenolone is a neurosteroid that modulates GABA receptors and magnesium glycinate supports relaxation and sleep, so the pair may complementarily... |
| Prochlorperazine | Synergy | Low magnesium increases vulnerability to torsades when QT-prolonging drugs are used. |
| Rabeprazole | Synergy | Magnesium supplementation may help correct low magnesium during PPI therapy, but severe PPI-associated hypomagnesemia can require stopping the PPI. |
| Ranolazine | Synergy | Ranolazine can prolong the QT interval, and torsades risk rises when magnesium is low. Maintaining normal magnesium helps stabilize repolarization... details → |
| Rhodiola Rosea | Synergy | Magnesium supports the stress response and nervous system relaxation, complementing rhodiola's adaptogenic effect on stress and fatigue. |
| Salmeterol/Fluticasone | Synergy | Magnesium repletion can support normal airway and cardiac physiology when deficiency is present. |
| Sotalol | Synergy | Sotalol prolongs the QT interval and can cause torsades de pointes, with the risk amplified by low magnesium. Magnesium supplementation helps... details → |
| Tacrolimus | Synergy | Magnesium can help correct tacrolimus-associated hypomagnesemia when monitored. |
| Taurine | Synergy | Taurine and magnesium are both calcium channel modulators with cardiovascular and sleep benefits; combined use is common in evening relaxation... |
| Torsemide | Synergy | Torsemide can lower magnesium in some patients, and magnesium replacement may be needed when deficiency is documented. |
| Vitamin B1 | Synergy | Magnesium is required for thiamine (B1) utilization. Magnesium deficiency impairs thiamine-dependent enzyme activity. |
| Vitamin B6 | Synergy | Vitamin B6 increases intracellular magnesium accumulation. Magnesium is required for B6 activation to its coenzyme form PLP. |
| Vitamin D2 | Synergy | Magnesium is required for the body to convert Vitamin D2 into its biologically active form. With low magnesium status, supplemental D2 is... |
| Vitamin D3 | Synergy | Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol. details → |
| Vitamin K2 | Synergy | Magnesium supports the vitamin D activation and calcium handling that vitamin K2 then directs into bone, complementing K2's role in mineralization. |
| Ziprasidone | Synergy | Low magnesium can increase torsades de pointes risk in patients taking QT-prolonging drugs such as ziprasidone. |
Go deeper
The full magnesium glycinate profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common magnesium glycinate questions.
Quick answers drawn from the table above.
What interacts with Magnesium Glycinate?
In the NutriStack database, Magnesium Glycinate has 98 documented interactions with other supplements and medications. The most notable include Amlodipine, Calcitriol, Candesartan, Captopril, and Cinacalcet.
What works well with Magnesium Glycinate?
Magnesium Glycinate pairs synergistically with Amiodarone, Apigenin, Ashwagandha, Boron, and Chlorthalidone in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Magnesium Glycinate with Amlodipine?
NutriStack classifies the Magnesium Glycinate and Amlodipine pairing as caution: Both amlodipine and magnesium act as calcium channel blockers through related mechanisms, creating additive hypotensive effects. Amlodipine blocks L-type voltage-gated... Oral magnesium supplementation is generally safe at moderate doses (200-350 mg/day supplemental elemental magnesium) with amlodipine, but monitor...
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