Supplement·Interactions·Reviewed June 9, 2026
Magnesium L-Threonate interactions.
Magnesium L-Threonate has 15 documented interactions in the NutriStack database: 4 that need timing or caution and 11 that work synergistically. The full list, with what each pairing does, is below.
Magnesium L-Threonate at a glance.
A quick, data-grounded summary. The full table is below.
Magnesium L-Threonate has 15 documented interactions in the NutriStack database: 4 that need timing or caution and 11 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with magnesium l-threonate.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Timing Sensitive | High-dose calcium and magnesium compete for absorption when taken simultaneously. details → |
| Ciprofloxacin | Timing Sensitive | All forms of supplemental magnesium, including magnesium L-threonate used for cognitive support, chelate ciprofloxacin in the gut and reduce its... details → |
| Iron | Timing Sensitive | Magnesium and iron can compete for absorption when taken together. Separate for optimal absorption of both. |
| Levothyroxine | Timing Sensitive | Magnesium L-threonate has not been studied directly with levothyroxine, but it supplies magnesium ions that may interfere with thyroid hormone... |
| Apigenin | Synergy | Both promote relaxation and sleep through GABAergic and glutamate-modulating pathways. |
| Ashwagandha | Synergy | Both promote relaxation and support sleep quality through complementary mechanisms. |
| Citicoline | Synergy | Both cross the blood-brain barrier to support cognitive function. Magnesium enhances synaptic plasticity; citicoline supports membrane phospholipid... |
| Creatine | Synergy | Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine. |
| L-Theanine | Synergy | L-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited. |
| Lion's Mane | Synergy | Both support neuroplasticity through different mechanisms. Magnesium L-threonate enhances synaptic density; lion's mane promotes NGF synthesis. |
| Melatonin | Synergy | Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary. |
| Potassium | Synergy | Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize. details → |
| Vitamin B1 | Synergy | Magnesium is required for thiamine (B1) utilization. Magnesium deficiency impairs thiamine-dependent enzyme activity. |
| Vitamin B6 | Synergy | Vitamin B6 increases intracellular magnesium accumulation. Magnesium is required for B6 activation to its coenzyme form PLP. |
| Vitamin D3 | Synergy | Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol. details → |
The full magnesium l-threonate profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common magnesium l-threonate questions.
Quick answers drawn from the table above.
What interacts with Magnesium L-Threonate?
In the NutriStack database, Magnesium L-Threonate has 15 documented interactions with other supplements and medications. The most notable include Calcium, Ciprofloxacin, Iron, Levothyroxine, and Apigenin.
What works well with Magnesium L-Threonate?
Magnesium L-Threonate pairs synergistically with Apigenin, Ashwagandha, Citicoline, Creatine, and L-Theanine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Magnesium L-Threonate with Calcium?
NutriStack classifies the Magnesium L-Threonate and Calcium pairing as timing sensitive: High-dose calcium and magnesium compete for absorption when taken simultaneously. If taking high doses (>500mg each), separate by 2+ hours. Moderate doses can be taken together.
Check your whole stack
See how magnesium l-threonate fits your routine.
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