Supplement·Interactions·Reviewed June 9, 2026
Nicotinamide Riboside interactions.
Nicotinamide Riboside has 4 documented interactions in the NutriStack database: 1 that need timing or caution and 3 that work synergistically. The full list, with what each pairing does, is below.
Nicotinamide Riboside at a glance.
A quick, data-grounded summary. The full table is below.
Nicotinamide Riboside has 4 documented interactions in the NutriStack database: 1 that need timing or caution and 3 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with nicotinamide riboside.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Timing Sensitive | Both NR and berberine are promoted for metabolic and mitochondrial support, but they act through different mechanisms (NAD+ repletion versus AMPK... |
| Coenzyme Q10 | Synergy | NAD+ (replenished by NR) and coenzyme Q10 act at sequential points of the mitochondrial electron transport chain: NADH delivers electrons to Complex... |
| Resveratrol | Synergy | NR raises cellular NAD+ levels, and resveratrol is a putative SIRT1 activator. Because sirtuins consume NAD+ as a cosubstrate, the two are... |
| Vitamin B12 | Synergy | Fatigue and low-energy symptoms attributed to declining NAD+ overlap substantially with symptoms of vitamin B12 deficiency, which is a far more... |
The full nicotinamide riboside profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common nicotinamide riboside questions.
Quick answers drawn from the table above.
What interacts with Nicotinamide Riboside?
In the NutriStack database, Nicotinamide Riboside has 4 documented interactions with other supplements and medications. The most notable include Berberine, Coenzyme Q10, Resveratrol, and Vitamin B12.
What works well with Nicotinamide Riboside?
Nicotinamide Riboside pairs synergistically with Coenzyme Q10, Resveratrol, and Vitamin B12 in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Nicotinamide Riboside with Berberine?
NutriStack classifies the Nicotinamide Riboside and Berberine pairing as timing sensitive: Both NR and berberine are promoted for metabolic and mitochondrial support, but they act through different mechanisms (NAD+ repletion versus AMPK activation and... These can be combined for metabolic support. Because berberine can lower blood glucose and cause GI upset, monitor glucose if you take antidiabetic...
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