Supplement·Interactions·Reviewed June 9, 2026
Olive Leaf Extract interactions.
Olive Leaf Extract has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Olive Leaf Extract at a glance.
A quick, data-grounded summary. The full table is below.
Olive Leaf Extract has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with olive leaf extract.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Antihypertensives | Caution | Olive leaf extract has Captopril-comparable blood pressure lowering effects (500mg BID). Oleuropein is a CYP3A4 mechanism-based inhibitor. |
| Berberine | Caution | Both olive leaf extract and berberine can lower blood glucose and blood pressure, so combining them may produce additive hypoglycemic and... details → |
| Garlic Extract | Caution | Olive leaf extract and garlic extract both modestly lower blood pressure, so combined use may produce additive hypotensive effects. details → |
| Lisinopril | Synergy | Olive Leaf Extract lowers blood pressure (about 4-11 mm Hg systolic depending on dose) and was non-inferior to captopril for stage 1 hypertension in... details → |
| Quercetin | Synergy | Olive leaf polyphenols and quercetin are complementary antioxidant and anti-inflammatory flavonoids that may also additively support healthy blood... |
The full olive leaf extract profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common olive leaf extract questions.
Quick answers drawn from the table above.
What interacts with Olive Leaf Extract?
In the NutriStack database, Olive Leaf Extract has 5 documented interactions with other supplements and medications. The most notable include Antihypertensives, Berberine, Garlic Extract, Lisinopril, and Quercetin.
What works well with Olive Leaf Extract?
Olive Leaf Extract pairs synergistically with Lisinopril and Quercetin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Olive Leaf Extract with Antihypertensives?
NutriStack classifies the Olive Leaf Extract and Antihypertensives pairing as caution: Olive leaf extract has Captopril-comparable blood pressure lowering effects (500mg BID). Oleuropein is a CYP3A4 mechanism-based inhibitor. Monitor blood pressure closely. May need medication dose adjustment.
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