Supplement·Interactions·Reviewed June 9, 2026
Passionflower interactions.
Passionflower has 7 documented interactions in the NutriStack database: 6 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Passionflower at a glance.
A quick, data-grounded summary. The full table is below.
Passionflower has 7 documented interactions in the NutriStack database: 6 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with passionflower.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alprazolam | Caution | Passionflower has measurable anxiolytic and GABA-related CNS activity. Alprazolam is a benzodiazepine sedative, so the combination may cause more... |
| Clonazepam | Caution | Passionflower can have calming CNS effects and GABA-related activity. Clonazepam is a long-acting benzodiazepine, so additive sedation may last... |
| GABA | Caution | Both target GABAergic tone, so combining supplemental GABA with passionflower can produce additive calming and sedative effects. |
| Lorazepam | Caution | Passionflower has anxiolytic and GABA-related activity that may stack with lorazepam's benzodiazepine effect. The result can be more sedation,... |
| Melatonin | Caution | Passionflower adds GABAergic sedation on top of melatonin's sleep-promoting effect, increasing overall drowsiness and next-morning grogginess in... |
| Valerian Root | Caution | Both herbs are sedative and GABAergic, so combining them produces additive drowsiness and CNS depression, an effect used in some combination sleep... details → |
| L-Theanine | Synergy | Both calm the nervous system mainly through GABA pathways, so combining them can produce additive anxiety-reducing and sleep-supporting effects. |
The full passionflower profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common passionflower questions.
Quick answers drawn from the table above.
What interacts with Passionflower?
In the NutriStack database, Passionflower has 7 documented interactions with other supplements and medications. The most notable include Alprazolam, Clonazepam, GABA, Lorazepam, and Melatonin.
What works well with Passionflower?
Passionflower pairs synergistically with L-Theanine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Passionflower with Alprazolam?
NutriStack classifies the Passionflower and Alprazolam pairing as caution: Passionflower has measurable anxiolytic and GABA-related CNS activity. Alprazolam is a benzodiazepine sedative, so the combination may cause more drowsiness, impaired... Avoid combining passionflower with alprazolam unless your prescriber agrees. If used, start with the lowest possible supplement dose, avoid alcohol...
Check your whole stack
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