Supplement·Interactions·Reviewed June 9, 2026
Phosphatidylserine interactions.
Phosphatidylserine has 7 documented interactions in the NutriStack database: 7 that work synergistically. The full list, with what each pairing does, is below.
Phosphatidylserine at a glance.
A quick, data-grounded summary. The full table is below.
Phosphatidylserine has 7 documented interactions in the NutriStack database: 7 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with phosphatidylserine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Bacopa Monnieri | Synergy | Phosphatidylserine supports neuronal membrane integrity and stress-axis modulation while Bacopa Monnieri enhances cholinergic signaling and synaptic... |
| Citicoline | Synergy | Citicoline supports phospholipid synthesis broadly, including phosphatidylserine. Together they comprehensively support neuronal membrane health. |
| Fish Oil | Synergy | Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes. |
| Fish Oil Triple Strength | Synergy | Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes. |
| Krill Oil | Synergy | Phosphatidylserine is a phospholipid that benefits from omega-3 DHA, which is preferentially incorporated into PS in brain membranes. |
| Lion's Mane | Synergy | The pair supports neuronal structure and signaling, with Lion's Mane stimulating neurotrophic factors and Phosphatidylserine maintaining neuronal... |
| Phosphatidylcholine | Synergy | Phosphatidylcholine and phosphatidylserine are complementary membrane phospholipids that together support neuronal membrane integrity and cognitive... |
The full phosphatidylserine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common phosphatidylserine questions.
Quick answers drawn from the table above.
What interacts with Phosphatidylserine?
In the NutriStack database, Phosphatidylserine has 7 documented interactions with other supplements and medications. The most notable include Bacopa Monnieri, Citicoline, Fish Oil, Fish Oil Triple Strength, and Krill Oil.
What works well with Phosphatidylserine?
Phosphatidylserine pairs synergistically with Bacopa Monnieri, Citicoline, Fish Oil, Fish Oil Triple Strength, and Krill Oil in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Phosphatidylserine with Bacopa Monnieri?
NutriStack classifies the Phosphatidylserine and Bacopa Monnieri pairing as synergy: Phosphatidylserine supports neuronal membrane integrity and stress-axis modulation while Bacopa Monnieri enhances cholinergic signaling and synaptic remodeling, giving... Combine for cognitive aging or general memory support. A typical pairing is about 100 to 300 mg phosphatidylserine daily with a standardized Bacopa...
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