Supplement·Interactions·Reviewed June 9, 2026
Pine Bark Extract interactions.
Pine Bark Extract has 9 documented interactions in the NutriStack database: 3 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Pine Bark Extract at a glance.
A quick, data-grounded summary. The full table is below.
Pine Bark Extract has 9 documented interactions in the NutriStack database: 3 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with pine bark extract.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alfuzosin | Caution | Alfuzosin is used for LUTS/BPH and can contribute to blood-pressure symptoms in susceptible patients, particularly with other agents that lower... |
| Tamsulosin | Caution | Tamsulosin can cause orthostatic hypotension, especially when it is started or restarted. Pine bark extract products such as pycnogenol have shown... |
| Warfarin | Caution | Pine bark extract (pycnogenol) inhibits platelet aggregation and reduces thromboxane generation. Combined with warfarin, these pharmacodynamic... |
| Grape Seed Extract | Synergy | Both are oligomeric proanthocyanidin sources with overlapping antioxidant and endothelial nitric-oxide-supporting effects, giving additive vascular... |
| L-Arginine | Synergy | Pine bark extract (Pycnogenol) combined with L-arginine improved erectile function and endothelial nitric oxide signaling in controlled clinical... |
| L-Citrulline | Synergy | L-citrulline raises plasma arginine and nitric oxide production, complementing pine bark extract's enhancement and protection of endothelial nitric... |
| Ramipril | Synergy | Pine Bark Extract (Pycnogenol) lowers blood pressure (about 3 mm Hg systolic and 3 mm Hg diastolic in a meta-analysis) and has independent... details → |
| Saw Palmetto | Synergy | Saw palmetto and pine bark extract (pycnogenol) are sometimes stacked in men's urinary and prostate formulas, pairing hormonal support with... |
| Vitamin C | Synergy | Vitamin C regenerates the oxidized flavonoid components of pine bark extract, helping sustain their antioxidant and endothelial-protective activity. |
The full pine bark extract profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common pine bark extract questions.
Quick answers drawn from the table above.
What interacts with Pine Bark Extract?
In the NutriStack database, Pine Bark Extract has 9 documented interactions with other supplements and medications. The most notable include Alfuzosin, Tamsulosin, Warfarin, Grape Seed Extract, and L-Arginine.
What works well with Pine Bark Extract?
Pine Bark Extract pairs synergistically with Grape Seed Extract, L-Arginine, L-Citrulline, Ramipril, and Saw Palmetto in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Pine Bark Extract with Alfuzosin?
NutriStack classifies the Pine Bark Extract and Alfuzosin pairing as caution: Alfuzosin is used for LUTS/BPH and can contribute to blood-pressure symptoms in susceptible patients, particularly with other agents that lower vascular tone. Pine bark... Start pine bark extract cautiously if you take alfuzosin. Monitor blood pressure and orthostatic symptoms during the first 1-2 weeks, and stop or...
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