Supplement·Interactions·Reviewed June 9, 2026
Psilocybin interactions.
Psilocybin has 5 documented interactions in the NutriStack database: 1 to avoid or watch closely and 4 that need timing or caution. The full list, with what each pairing does, is below.
Psilocybin at a glance.
A quick, data-grounded summary. The full table is below.
Psilocybin has 5 documented interactions in the NutriStack database: 1 to avoid or watch closely and 4 that need timing or caution. The full list, with what each pairing does, is below.
Everything that interacts with psilocybin.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Lithium Orotate | Contraindicated | Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological... |
| 5-HTP | Caution | 5-HTP increases serotonin synthesis and, combined with the serotonergic psychedelic psilocybin, raises the theoretical risk of excessive... |
| Fluoxetine | Caution | Fluoxetine substantially blunts psilocybin's psychedelic effects through chronic 5-HT2A receptor downregulation, and its very long half-life means... |
| Sertraline | Caution | Sertraline blocks the serotonin transporter and occupies postsynaptic 5-HT2A receptors over time, blunting psilocybin's intended psychedelic effect.... |
| St. John's Wort | Caution | St. John's Wort has serotonergic and weak monoamine-oxidase-modulating activity, so combining it with the serotonergic psychedelic psilocybin raises... |
The full psilocybin profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common psilocybin questions.
Quick answers drawn from the table above.
What interacts with Psilocybin?
In the NutriStack database, Psilocybin has 5 documented interactions with other supplements and medications. The most notable include Lithium Orotate, 5-HTP, Fluoxetine, Sertraline, and St. John's Wort.
What should you not take with Psilocybin?
Psilocybin is flagged against 1 substance in the database, including Lithium Orotate. Review these with a clinician before combining, especially alongside prescription medications.
Can you take Psilocybin with Lithium Orotate?
NutriStack classifies the Psilocybin and Lithium Orotate pairing as contraindicated: Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological reactions, making this... Do not combine. If you take any lithium-containing product, do not use psilocybin and seek medical advice.
Check your whole stack
See how psilocybin fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.