Supplement·Interactions·Reviewed June 9, 2026
Pterostilbene interactions.
Pterostilbene has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Pterostilbene at a glance.
A quick, data-grounded summary. The full table is below.
Pterostilbene has 5 documented interactions in the NutriStack database: 3 that need timing or caution and 2 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with pterostilbene.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Both pterostilbene and berberine activate AMPK and can lower blood glucose. Used together, and especially alongside antidiabetic medication, they... |
| Milk Thistle | Caution | Both pterostilbene and silymarin from milk thistle are metabolized by hepatic conjugation enzymes (glucuronidation and sulfation), and silymarin can... |
| Quercetin | Timing Sensitive | Quercetin inhibits several CYP450 enzymes and the efflux transporter P-glycoprotein. Co-administration could alter the metabolism and plasma levels... |
| Resveratrol | Synergy | Pterostilbene is the dimethylated analog of resveratrol with markedly higher oral bioavailability and a longer half-life. The two share overlapping... |
| Vitamin B12 | Synergy | Pterostilbene is frequently paired with NAD precursors to support sirtuin activity. Methyl-group sufficiency, supported by B12 and folate, becomes... |
The full pterostilbene profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common pterostilbene questions.
Quick answers drawn from the table above.
What interacts with Pterostilbene?
In the NutriStack database, Pterostilbene has 5 documented interactions with other supplements and medications. The most notable include Berberine, Milk Thistle, Quercetin, Resveratrol, and Vitamin B12.
What works well with Pterostilbene?
Pterostilbene pairs synergistically with Resveratrol and Vitamin B12 in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Pterostilbene with Berberine?
NutriStack classifies the Pterostilbene and Berberine pairing as caution: Both pterostilbene and berberine activate AMPK and can lower blood glucose. Used together, and especially alongside antidiabetic medication, they may produce additive... Monitor blood glucose if combining these, particularly in people taking insulin or oral hypoglycemics. Watch for signs of hypoglycemia and adjust...
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